Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Xu, Qingfu ; Pichichero, Michael E. ; Casey, Janet R. ; Zeng, Mingtao
Xu, Qingfu ; Pichichero, Michael E. ; Casey, Janet R. ; Zeng, Mingtao Less -
Description:
After our recent discovery of a Streptococcus pneumoniae 19A "superbug" (Legacy strain) that is resistant to all Food and Drug Administration-approved antimicrobial drugs for treatment of acute otitis media (AOM) in children, other S. pneumoniae isolates from children with AOM were characterized by multilocus sequence typing (MLST). Among 40 isolates studied, 16 (40%) were serotype 19A, and 9 (23%) were resistant to multiple antimicrobial drugs. Two others had unreported sequence types (STs) that expressed the 19A capsule, and 8 (88%) of the 9 multidrug-resistant strains were serotype 19A, including the Legacy strain with the new ST-2722. In genetic relatedness, ST-2722 belonged to a cluster of reported strains of S. pneumoniae in which all strains had 6 of the same alleles as ST-156. The multidrug-resistant strains related to ST-156 expressed different capsular serotypes: 9V, 14, 11A, 15C, and 19F.
Subject:
[+]
Base Sequence
Child
Communicable Diseases, Emerging
DNA, Bacterial
DNA Primers
Drug Resistance, Multiple, Bacterial
Genes, Bacterial
Humans
Microbial Sensitivity Tests
Molecular Sequence Data
Otitis Media
Phylogeny
Pneumococcal Infections
Sequence Homology, Nucleic Acid
Serotyping

Source:
Emerg Infect Dis. 15(4):547-551.
Document Type:
Journal Article
Place as Subject:
New York
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:0bc3fad5ad05fa5fc5f5c189c1acda07f9c14bb4fb146af1668ffa80d25dbbbf
File Type:

Supporting Files

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