Increase in Pilus Islet 2–encoded Pili among Streptococcus pneumoniae Isolates, Atlanta, Georgia, USA

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Zähner, Dorothea ; Gudlavalleti, Aditya ; Stephens, David S.
• Description:
  To define the prevalence of pilus islet 2 (PI-2)-encoded pili in Streptococcus pneumoniae in a geographically defined area, we examined 590 S. pneumoniae isolates from population-based surveillance of invasive pneumococcal disease in Atlanta, Georgia, USA, 1994-2006. In 2006, PI-2 was present in 21% of all invasive isolates, including serotypes 1 (100%), 7F (89%), 11A (21%), 19A (40%), and 19F (75%). Only serotype 19F is included in the 7-valent pneumococcal conjugate vaccine that is in use worldwide. In 1999, PI-2-containing isolates were of the same serotypes but accounted for only 3.6% of all invasive isolates. The increase of PI-2 in 2006 resulted predominantly from the emergence of serotype 19A isolates of sequence type 320 and the expansion of serotype 7F isolates. The increase in PI-2-containing isolates and the finding that isolates of all identified serotypes expressed highly conserved PI-2 pili supports their potential as a vaccine candidate.
• Subjects:
  DNA, Bacterial Drug Resistance, Multiple, Bacterial Fimbriae, Bacterial Genes, Bacterial Genetic Variation Humans Microbial Sensitivity Tests Pneumococcal Infections Research Sequence Analysis, DNA
• Source:
  Emerg Infect Dis. 16(6):955-962.
• Document Type:
  Journal Article
• Place as Subject:
  Georgia
• Location:
  North America
• Volume:
  16
• Issue:
  6
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:edda9eaa7bee96eb2e0be3b0e5b08e06ceb3bd3566b7f37d6342bc257b601a6e
• Download URL:
  https://stacks.cdc.gov/view/cdc/18175/cdc_18175_DS1.pdf
• File Type:
  [PDF - 258.34 KB ]