Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Zähner, Dorothea ; Gudlavalleti, Aditya ; Stephens, David S.
Zähner, Dorothea ; Gudlavalleti, Aditya ; Stephens, David S. Less -
Description:
To define the prevalence of pilus islet 2 (PI-2)-encoded pili in Streptococcus pneumoniae in a geographically defined area, we examined 590 S. pneumoniae isolates from population-based surveillance of invasive pneumococcal disease in Atlanta, Georgia, USA, 1994-2006. In 2006, PI-2 was present in 21% of all invasive isolates, including serotypes 1 (100%), 7F (89%), 11A (21%), 19A (40%), and 19F (75%). Only serotype 19F is included in the 7-valent pneumococcal conjugate vaccine that is in use worldwide. In 1999, PI-2-containing isolates were of the same serotypes but accounted for only 3.6% of all invasive isolates. The increase of PI-2 in 2006 resulted predominantly from the emergence of serotype 19A isolates of sequence type 320 and the expansion of serotype 7F isolates. The increase in PI-2-containing isolates and the finding that isolates of all identified serotypes expressed highly conserved PI-2 pili supports their potential as a vaccine candidate.
Subject:
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DNA, Bacterial Drug Resistance, Multiple, Bacterial Fimbriae, Bacterial Genes, Bacterial Genetic Variation Humans Microbial Sensitivity Tests Pneumococcal Infections Research Sequence Analysis, DNA
Source:
Emerg Infect Dis. 16(6):955-962.
Document Type:
Journal Article
Place as Subject:
Georgia
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:edda9eaa7bee96eb2e0be3b0e5b08e06ceb3bd3566b7f37d6342bc257b601a6e
Download URL:
https://stacks.cdc.gov/view/cdc/18175/cdc_18175_DS1.pdf
File Type:

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