Pigs as Source of Methicillin-Resistant Staphylococcus aureus CC398 Infections in Humans, Denmark

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Lewis, Hannah C. ; Mølbak, Kåre ; Reese, Catrin ; Aarestrup, Frank M. ; Selchau, Mette ; Sørum, Marit ; Skov, Robert L.
• Description:
  An emerging subtype of methicillin-resistant Staphylococcus aureus (MRSA), clonal complex (CC) 398, is associated with animals, particularly pigs. We conducted a matched case-control and a case-case study comparing 21 CC398 case-patients with 2 controls randomly selected from the Danish Civil Registry and 2 case-patients infected with MRSA other than CC398. On farms of case-patients, animals were examined for MRSA. Thirteen case-patients reported pig exposure. Living or working on farms with animals was an independent risk factor for CC398 in the case-control (matched odds ratio [MOR] 35.4, 95% confidence interval [CI] 2.7-469.8) and the case-case study (MOR 14.5, 95%CI 2.7-76.7). History of hospitalization was associated with an increased risk only in the case-control study (MOR 11.4, 95% CI 1.4-94.8). A total of 23 of 50 pigs on 4 of 5 farms were positive for CC398. Our results, corroborated by microbiologic testing, demonstrate that pigs are a source of CC398 in Denmark.
• Subjects:
  Animals Case-control Studies CC398 Community-acquired Infections Denmark Disease Reservoirs Domestic Swine (pig) Environmental Exposure Epidemiology Humans Methicillin Resistance Multivariate Analysis Research Staphylococcal Infections Staphylococcus Aureus Swine

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• Source:
  Emerg Infect Dis. 14(9):1383-1389
• Pubmed ID:
  18760004
• Pubmed Central ID:
  PMC2603104
• Document Type:
  Journal Article
• Volume:
  14
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:9f3dd2be86dbb389b982011dce605232f4c65a1fe00ff998a8c95f9bbd030cd5
• Download URL:
  https://stacks.cdc.gov/view/cdc/17142/cdc_17142_DS1.pdf
• File Type:
  [PDF - 281.73 KB ]