Mixture for Controlling Insecticide-Resistant Malaria Vectors

Pennetier, Cédric; Costantini, Carlo; Corbel, Vincent; Licciardi, Séverine; Dabiré, Roch K.; Lapied, Bruno; Chandre, Fabrice; Hougard, Jean-Marc

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Mixture for Controlling Insecticide-Resistant Malaria Vectors

Supporting Files Public Domain

Nov 2008
By Pennetier, Cédric ; Costantini, Carlo ; Corbel, Vincent ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Pennetier, Cédric ; Costantini, Carlo ; Corbel, Vincent ; Licciardi, Séverine ; Dabiré, Roch K. ; Lapied, Bruno ; Chandre, Fabrice ; Hougard, Jean-Marc
Description:

The spread of resistance to pyrethroids in the major Afrotropical malaria vectors Anopheles gambiae s.s. necessitates the development of new strategies to control resistant mosquito populations. To test the efficacy of nets treated with repellent and insecticide against susceptible and insecticide-resistant An. gambiae mosquito populations, we impregnated mosquito bed nets with an insect repellent mixed with a low dose of organophosphorous insecticide and tested them in a rice-growing area near Bobo-Dioulasso, Burkina Faso. During the first 2 weeks posttreatment, the mixture was as effective as deltamethrin alone and was more effective at killing An. gambiae that carried knockdown resistance (kdr) or insensitive acetylcholinesterase resistance (Ace1R) genes. The mixture seemed to not kill more susceptible genotypes for the kdr or Ace1R alleles. Mixing repellents and organophosphates on bed nets could be used to control insecticide-resistant malaria vectors if residual activity of the mixture is extended and safety is verified.
Subjects:

Acetylcholinesterase Alleles Animals Anopheles Anopheles Gambiae Bed Nets Burkina Faso Cholinesterase Inhibitors Deet Female Genes, Insect Humans Insecticide Resistance Insecticides Insect Repellents Insect Vectors Malaria Male Mixtures Mosquito Control Nitriles Organothiophosphorus Compounds Piperidines Pyrethrins Pyrethroid Repellents Research Resistance
Source:

Emerg Infect Dis. 14(11):1707-1714
Pubmed ID:

18976553
Pubmed Central ID:

PMC2630727
Document Type:

Journal Article
Volume:

14
Issue:

11
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:d2a8ebcd795389181e94749287cf5acfc0af74fb59c87c4120e72d548b7a7f74
Download URL:

https://stacks.cdc.gov/view/cdc/17141/cdc_17141_DS1.pdf
File Type:

[PDF - 311.22 KB ]

File Language:

English

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