Naloxone Use During Pregnancy – Data from 26 U.S. Jurisdictions, 2019-2020

Details

• Alternative Title:
  J Addict Med
• Personal Author:
  Board, Amy ; D’Angelo, Denise V. ; Miele, Kathryn ; Asher, Alice ; von Essen, Beatriz Salvesen ; Denny, Clark H ; Terplan, Mishka ; Dunkley, Janae ; Kim, Shin Y.
• Description:
  Objectives:
  
  We aimed to determine the prevalence of self-reported naloxone use during pregnancy among people in the U.S. with a recent live birth. A secondary objective was to characterize people at increased risk for overdose who did and did not use naloxone.
  
  Methods:
  
  We analyzed data from the Pregnancy Risk Assessment Monitoring System from 26 U.S. jurisdictions that conducted an opioid supplement survey from 2019 through 2020. Respondents with increased risk of experiencing an opioid overdose were identified based on self-reported use of illicit amphetamines, heroin, cocaine, or receiving medication for opioid use disorder (MOUD) during pregnancy. Weighted prevalence estimates and 95% confidence intervals were calculated for reported naloxone use at any point during pregnancy among people with an increased risk of overdose.
  
  Results:
  
  Naloxone use during pregnancy was reported by < 1% of the overall study population (unweighted N=88/34,528). Prevalence of naloxone use was 5.0% (95% CI: 0.0-10.6) among respondents who reported illicit amphetamine use, 15.2% (1.8-28.6) among those who reported heroin use, and 17.6% (0.0-38.1) among those who reported cocaine use. Naloxone use was 14.5% (8.4-20.6) among those who reported taking MOUD. Among people with increased risk of overdose, no significant differences in naloxone use were observed by age, race/ethnicity, education level, residential metropolitan status, or insurance status.
  
  Conclusions:
  
  Prevalence of naloxone use among people with an increased risk of overdose during pregnancy ranged from 5.0% to 17.6%. Access to naloxone, overdose prevention education, and treatment for substance use disorders may help reduce morbidity and mortality.
  
  
• Subjects:
  Adolescent Adult Drug Overdose Female Humans Naloxone Narcotic Antagonists Opioid-Related Disorders Pregnancy Pregnancy Complications Prevalence Self Report United States Young Adult

  More +
• Keywords:
  Naloxone Opioid Overdose PRAMS Stimulant
• Source:
  J Addict Med. 18(6):711-714
• Pubmed ID:
  38912696
• Pubmed Central ID:
  PMC11537837
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  18
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:f416c5078de4afcdf8a6de5026c299a1b55c9fbaeae16174a3477568ae1ea1e205046cfdf03fce5b229edff2a60c1ccb2f033f6b55ce83f5d93a81026d6d846e
• Download URL:
  https://stacks.cdc.gov/view/cdc/169372/cdc_169372_DS1.pdf
• File Type:
  [PDF - 164.82 KB ]