Antimicrobial Drug Use and Resistance in Europe

van de Sande-Bruinsma, Nienke; Grundmann, Hajo; Verloo, Didier; Tiemersma, Edine; Monen, Jos; Goossens, Herman; Ferech, Matus

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Antimicrobial Drug Use and Resistance in Europe

Supporting Files Public Domain

Nov 2008
By van de Sande-Bruinsma, Nienke ; Grundmann, Hajo ; Verloo, Didier ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

van de Sande-Bruinsma, Nienke ; Grundmann, Hajo ; Verloo, Didier ; Tiemersma, Edine ; Monen, Jos ; Goossens, Herman ; Ferech, Matus
Corporate Authors:

European Antimicrobial Resistance Surveillance System and European Surveillance of Antimicrobial Consumption Project Groups
Description:

Our study confronts the use of antimicrobial agents in ambulatory care with the resistance trends of 2 major pathogens, Streptococcus pneumoniae and Escherichia coli, in 21 European countries in 2000-2005 and explores whether the notion that antimicrobial drug use determines resistance can be supported by surveillance data at national aggregation levels. The data obtained from the European Surveillance of Antimicrobial Consumption and the European Antimicrobial Resistance Surveillance System suggest that variation of consumption coincides with the occurrence of resistance at the country level. Linear regression analysis showed that the association between antimicrobial drug use and resistance was specific and robust for 2 of 3 compound pathogen combinations, stable over time, but not sensitive enough to explain all of the observed variations. Ecologic studies based on routine surveillance data indicate a relation between use and resistance and support interventions designed to reduce antimicrobial drug consumption at a national level in Europe.
Subjects:

Ambulatory Care Anti-Bacterial Agents Drug Resistance, Bacterial Drug Utilization Escherichia Coli Infections Hospitals Humans Linear Models Pneumococcal Infections Product Surveillance, Postmarketing Retrospective Studies
Source:

Emerg Infect Dis. 14(11):1722-1730
Pubmed ID:

18976555
Pubmed Central ID:

PMC2630720
Document Type:

Journal Article
Place as Subject:

Europe
Volume:

14
Issue:

11
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:24ca8b354bdef0f1861975db334fc5025b536bd3a4c27da717593c1739cb3592
Download URL:

https://stacks.cdc.gov/view/cdc/16817/cdc_16817_DS1.pdf
File Type:

[PDF - 206.81 KB ]

File Language:

English

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