Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
De Palma, Armando M. ; Pürstinger, Gerhard ; Wimmer, Eva ; Patick, Amy K. ; Andries, Koen ; ... More +
De Palma, Armando M. ; Pürstinger, Gerhard ; Wimmer, Eva ; Patick, Amy K. ; Andries, Koen ; Rombaut, Bart ; De Clercq, Erik ; Neyts, Johan Less -
Description:
In 1988, the World Health Assembly launched the Global Polio Eradication Initiative, which aimed to use large-scale vaccination with the oral vaccine to eradicate polio worldwide by the year 2000. Although important progress has been made, polio remains endemic in several countries. Also, the current control measures will likely be inadequate to deal with problems that may arise in the postpolio era. A panel convoked by the National Research Council concluded that the use of antiviral drugs may be essential in the polio eradication strategy. We here report on a comparative study of the antipoliovirus activity of a selection of molecules that have previously been reported to be inhibitors of picornavirus replication and discuss their potential use, alone or in combination, for the treatment or prophylaxis of poliovirus infection.
Subject:
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Antiviral Agents
HeLa Cells
Humans
Poliomyelitis
Poliovirus
Protein Binding
Synopsis
Viral Proteins
Virus Replication
Antiviral Agents

Source:
Emerg Infect Dis. 14(4):545-551.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:5517a126a7c26213e07740c9e4dae1c97236cac82eabcbf4d59a8a8e0b475b31
File Type:

Supporting Files

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