Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Coque, Teresa M. ; Novais, Ângela ; Carattoli, Alessandra ; Poirel, Laurent ; Pitout, Johann ; ... More +
Coque, Teresa M. ; Novais, Ângela ; Carattoli, Alessandra ; Poirel, Laurent ; Pitout, Johann ; Peixe, Luísa ; Baquero, Fernando ; Cantón, Rafael ; Nordmann, Patrice ; Less -
Description:
We analyzed 43 CTX-M-15-producing Escherichia coli isolates and 6 plasmids encoding the blaCTX-M-15 gene from Canada, India, Kuwait, France, Switzerland, Portugal, and Spain. Most isolates belonged to phylogroups B2 (50%) and D (25%). An EC-B2 strain of clonal complex sequence type (ST) 131 was detected in all countries; other B2 isolates corresponded to ST28, ST405, ST354, and ST695 from specific areas. EC-D strains were clonally unrelated but isolates from 3 countries belonged to ST405. All CTX-M-15 plasmids corresponded to IncFII group with overrepresentation of 3 HpaI-digested plasmid DNA profiles (A, B and C; 85-120kb, similarity > or =70%). Plasmid A was detected in EC-B2 strains (ST131, ST354, or ST405), plasmid C was detected in B2 and D strains, and plasmid B was confined to worldwide-disseminated ST131. Most plasmids contained blaOXA-1, aac(6')-Ib-cr, and blaTEM-1. Worldwide dissemination of CTX-M-15 seems to be determined by clonal complexes ST131 and ST405 and multidrug-resistant IncFII plasmids.
Subject:
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Beta-Lactamases
Beta-Lactam Resistance
Drug Resistance, Multiple, Bacterial
Escherichia Coli Infections
Escherichia Coli Proteins
Humans
Plasmids
Research

Source:
Emerg Infect Dis. 14(2):195-200. ;
Document Type:
Journal Article ;
Place as Subject:
Canada ; Europe ; India ; Kuwait ;
Canada ; Europe ; India ; Kuwait ; Less -
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:6b6cca543d697a6949bd5a0ef9f44d604b34ee04ce1237b73deef83df5cb6ed1
File Type:

Supporting Files

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  	07-0350_app-s2.gif	gif
  	07-0350_appT-s1.pdf	pdf
  	07-0350_finalR.nxml	txt
  	license.txt	txt

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