CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.
As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.
i
Global estimates of rotavirus hospitalizations among children <5 years in 2019 and current and projected impacts of rotavirus vaccination
-
4 30 2022
-
-
Source: J Pediatric Infect Dis Soc. 11(4):149-158
[PDF-1.04 MB]
Details:
-
Alternative Title:J Pediatric Infect Dis Soc
-
Personal Author:
-
Description:Background:
Rotavirus vaccine impact on rotavirus hospitalizations is not well-documented globally. We performed a systematic review to estimate the number of rotavirus hospitalizations that 1) occur annually, 2) are currently prevented by rotavirus vaccines, and 3) could be prevented with improved vaccine coverage and universal vaccine introduction.
Methods:
We systematically reviewed articles indexed in the PubMed database published from 1 January 2000 to 31 December 2019. We included all primary peer-reviewed studies with rotavirus hospitalization rates for children <5 years that reported data prior to vaccine introduction, utilized at least one continuous year of data collection, and collected hospitalization data after 2000 using active surveillance. We grouped pre-vaccine country estimates by childhood mortality strata and calculated the median rate among each group. We then assigned the mortality stratum-specific hospitalization rates to each country and calculated the number of rotavirus hospitalizations by country, mortality strata, and WHO region.
Results:
Our search strategy identified 4,590 manuscripts, of which 32 were included in the final dataset. In 2019, an estimated 1,760,113 (Interquartile range [IQR]: 1,422,645–2,925,372) rotavirus hospitalizations occurred globally, with 524,871 (IQR: 415,987–814,835) prevented by rotavirus vaccination. With universal introduction of rotavirus vaccines and increased vaccine coverage, we estimate that an additional 751,609 (IQR:607,671–1,318,807) rotavirus hospitalizations can be prevented annually.
Conclusions:
This analysis highlights the continued burden of rotavirus hospitalizations among children <5 years. A large, preventable proportion of this burden could be eliminated by expanding introductions to new countries and increasing rotavirus vaccine coverage to levels seen with other childhood vaccinations.
-
Subjects:
-
Keywords:
-
Source:
-
Pubmed ID:34904636
-
Pubmed Central ID:PMC11495151
-
Document Type:
-
Funding:
-
Volume:11
-
Issue:4
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type:
