Cross-subtype Immunity against Avian Influenza in Persons Recently Vaccinated for Influenza

Gioia, Cristiana; Castilletti, Concetta; Tempestilli, Massimo; Piacentini, Paola; Bordi, Licia; Chiappini, Roberta; Agrati, Chiara; Squarcione, Salvatore; Ippolito, Giuseppe; Puro, Vincenzo; Capobianchi, Maria R.; Poccia, Fabrizio

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Cross-subtype Immunity against Avian Influenza in Persons Recently Vaccinated for Influenza

Published Date:

Jan 2008

Source:

Emerg Infect Dis. 14(1):121-128.

[PDF-305.94 KB]

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Alternative Title:

Emerg Infect Dis

Personal Author:

Gioia, Cristiana ; Castilletti, Concetta ; Tempestilli, Massimo ; Piacentini, Paola ; Bordi, Licia ; ... More ▼

Description:

Avian influenza virus (H5N1) can be transmitted to humans, resulting in a severe or fatal disease. The aim of this study was to evaluate the immune cross-reactivity between human and avian influenza (H5N1) strains in healthy donors vaccinated for seasonal influenza A (H1N1)/(H3N2). A small frequency of CD4 T cells specific for subtype H5N1 was detected in several persons at baseline, and seasonal vaccine administration enhanced the frequency of such reactive CD4 T cells. We also observed that seasonal vaccination is able to raise neutralizing immunity against influenza (H5N1) in a large number of donors. No correlation between influenza-specific CD4 T cells and humoral responses was observed. N1 may possibly be a target for both cellular and humoral cross-type immunity, but additional experiments are needed to clarify this point. These findings highlight the possibility of boosting cross-type cellular and humoral immunity against highly pathogenic avian influenza A virus subtype H5N1 by seasonal influenza vaccination.

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Document Type:

Journal Article

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Emerging Infectious Diseases

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Cross-subtype Immunity against Avian Influenza in Persons Recently Vaccinated for Influenza

Cross-subtype Immunity against Avian Influenza in Persons Recently Vaccinated for Influenza

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