Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Gioia, Cristiana ; Castilletti, Concetta ; Tempestilli, Massimo ; Piacentini, Paola ; Bordi, Licia ; ... More +
Gioia, Cristiana ; Castilletti, Concetta ; Tempestilli, Massimo ; Piacentini, Paola ; Bordi, Licia ; Chiappini, Roberta ; Agrati, Chiara ; Squarcione, Salvatore ; Ippolito, Giuseppe ; Puro, Vincenzo ; Capobianchi, Maria R. ; Poccia, Fabrizio Less -
Description:
Avian influenza virus (H5N1) can be transmitted to humans, resulting in a severe or fatal disease. The aim of this study was to evaluate the immune cross-reactivity between human and avian influenza (H5N1) strains in healthy donors vaccinated for seasonal influenza A (H1N1)/(H3N2). A small frequency of CD4 T cells specific for subtype H5N1 was detected in several persons at baseline, and seasonal vaccine administration enhanced the frequency of such reactive CD4 T cells. We also observed that seasonal vaccination is able to raise neutralizing immunity against influenza (H5N1) in a large number of donors. No correlation between influenza-specific CD4 T cells and humoral responses was observed. N1 may possibly be a target for both cellular and humoral cross-type immunity, but additional experiments are needed to clarify this point. These findings highlight the possibility of boosting cross-type cellular and humoral immunity against highly pathogenic avian influenza A virus subtype H5N1 by seasonal influenza vaccination.
Subject:
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Adult
Antibody Formation
Avian Influenza
Cross Reactions
Drug Administration Schedule
Female
Health Personnel
Hemagglutinins
Heterotypic Immunity
Human Influenza
Humans
Immunity, Cellular
Influenza A Virus, H1N1 Subtype
Influenza A Virus, H3N2 Subtype
Influenza A Virus, H5N1 Subtype
Influenza Vaccines
Male
Middle Aged
Research
Vaccination
Research

Source:
Emerg Infect Dis. 14(1):121-128.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:bb03ffc8d09ed7778859fc71c4a1e541d4492bd98dc8be29090198ec1a79d88e
File Type:

Supporting Files

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