Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Pitout, Johann D.D. ; Gregson, Daniel B. ; Church, Deirdre L. ; Laupland, Kevin B.
Pitout, Johann D.D. ; Gregson, Daniel B. ; Church, Deirdre L. ; Laupland, Kevin B. Less -
Description:
In the Calgary Health Region during 2000-2003, prospective, active, population-based laboratory surveillance for all cefoxitin-resistant Escherichia coli isolates was performed. Isolates were screened with an inhibitor-based disk test, and plasmid-mediated types were identified by multiplex PCR with sequencing. A total of 369 AmpC beta-lactamase-producing E. coli isolates were identified; annual incidence rates were 1.7, 4.3, 11.2, and 15 per 100,000 residents for each year, respectively. AmpC beta-lactamase-producing E. coli was 5x more likely to be isolated from female than male patients across all age groups except < 1 year. Of these isolates, 83% were community onset, and urine was the principal site of isolation (90% of patients). PCR showed that 125 (34%) were positive for bla(cmy) genes; sequencing identified these enzymes to be CMY-2. In this large Canadian region, AmpC beta-lactamase-producing E. coli is an emerging community pathogen that commonly causes urinary tract infections in older women.
Subject:
[+]
Adolescent
Adult
Aged
Aged, 80 And Over
Anti-Bacterial Agents
Bacterial Proteins
Beta-Lactamases
Cefoxitin
Child
Child, Preschool
Communicable Diseases, Emerging
Community-Acquired Infections
Drug Resistance, Bacterial
Escherichia Coli
Escherichia Coli Infections
Female
Genes, Bacterial
Humans
Incidence
Infant
Male
Middle Aged
Prospective Studies
Sentinel Surveillance
Urine

Source:
Emerg Infect Dis. 13(3):443-448.
Document Type:
Journal Article
Place as Subject:
Canada
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:d2d4d285c4e42fbe2c68d048cc42300d1c37f5112c99b1b382a1e1e2e2cb86f9
File Type:

Supporting Files

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