Blood Transfusion and Spread of Variant Creutzfeldt-Jakob Disease

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Dietz, Klaus ; Raddatz, Günter ; Wallis, Jonathan ; Müller, Norbert ; Zerr, Inga ; Duerr, Hans-Peter ; Lefèvre, Hans ; Seifried, Erhard ; Löwer, Johannes
• Description:
  Variant Creutzfeldt-Jakob disease (vCJD) may be transmissible by blood. To prevent secondary transmission through blood components, several countries have started to exclude as donors persons who have received a blood transfusion. We investigated the effectiveness of this measure by using a dynamic age-structured model. It is the first such model based on epidemiologic data: 1) blood donor activities, 2) a case-control study on CJD, 3) age distribution of recipients, and 4) death of recipients of blood transfusions. The model predicts that an infection like vCJD, which has been introduced into the population by the alimentary route, could not become endemic by transfusion alone and that only <1% of cases would be avoided by excluding from blood donation those persons who have received a transfusion.
• Subjects:
  Adolescent Adult Aged Biometry Blood Donors Blood Transfusion Communicable Diseases Creutzfeldt-Jakob Syndrome Emerging Endemic Diseases Epidemiology Humans Incidence Infection Middle Aged Models Models, Biological Prevalence Research Risk Assessment Risk Factors Theoretical Variant Creutzfeldt-Jakob Disease

  More +
• Source:
  Emerg Infect Dis. 13(1):89-96.
• Document Type:
  Journal Article
• Volume:
  13
• Issue:
  1
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:bc33c77a2453f2bdf1a8e8265e2d79ef17ea7a44cb181b0f5d36df1103178e5e
• Download URL:
  https://stacks.cdc.gov/view/cdc/16308/cdc_16308_DS1.pdf
• File Type:
  [PDF - 506.58 KB ]