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Blood Transfusion and Spread of Variant Creutzfeldt-Jakob Disease
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  1. Sporadic Creutzfeldt-Jakob Disease in 2 Plasma Product Recipients, United Kingdom
    Personal Author:
    Urwin, Patrick; Thanigaikumar, Kumar; Ironside, James W.; Molesworth, Anna; Knight, Richard S.; Hewitt, Patricia E.; Llewelyn, Charlotte; Mackenzie, Jan; Will, Robert G.;
    Published:
    Jun 2017
    Source:
    Emerg Infect Dis. 23(6):893-897.
    Description:
    Sporadic Creutzfeldt-Jakob disease (sCJD) has not been previously reported in patients with clotting disorders treated with fractionated plasma products. We report 2 cases of sCJD identified in the United Kingdom in patients with a history of extende...
    File Type:
    Filetype[PDF - 1.27 MB]
  2. Variant Creutzfeldt-Jakob Disease Death, United States
    Personal Author:
    Belay, Ermias D.; Sejvar, James J.; Shieh, Wun-Ju; Wiersma, Steven T.; Zou, Wen-Quan; Gambetti, Pierluigi; Hunter, Stephen; Maddox, Ryan A.; Crockett, Landis; Zaki, Sherif R.; Schonberger, Lawrence B.;
    Published:
    Sep 2005
    Source:
    Emerg Infect Dis. 11(9):1351-1354.
    Description:
    The only variant Creutzfeldt-Jakob disease (vCJD) patient identified in the United States died in 2004, and the diagnosis was confirmed by analysis of autopsy tissue. The patient likely acquired the disease while growing up in Great Britain before im...
    File Type:
    Filetype[PDF - 179.39 KB]
  3. Distribution and Quantitative Estimates of Variant Creutzfeldt-Jakob Disease Prions in Tissues of Clinical and Asymptomatic Patients
    Personal Author:
    Douet, Jean Y.; Lacroux, Caroline; Aron, Naima; Head, Mark W.; Lugan, Séverine; Tillier, Cécile; Huor, Alvina; Cassard, Hervé; Arnold, Mark; Beringue, Vincent; Ironside, James W.; Andréoletti, Olivier;
    Published:
    Jun 2017
    Source:
    Emerg Infect Dis. 23(6):946-956.
    Description:
    In the United-Kingdom, ≈1 of 2,000 persons could be infected with variant Creutzfeldt-Jakob disease (vCJD). Therefore, risk of transmission of vCJD by medical procedures remains a major concern for public health authorities. In this study, we used ...
    File Type:
    Filetype[PDF - 1.78 MB]
  4. Is Creutzfeldt-Jakob disease transmitted in blood?
    Personal Author:
    Ricketts, M. N.; Cashman, N. R.; Stratton, E. E.; ElSaadany, S.;
    Published:
    1997 Apr-Jun
    Source:
    Emerg Infect Dis. 3(2):155-163.
    Description:
    Creutzfeldt-Jakob disease (CJD) has been considered infectious since the mid-1960s, but its transmissibility through the transfusion of blood or blood products is controversial. The causative agent's novel undefined nature and resistance to standard ...
    File Type:
    Filetype[PDF - 43.72 KB]
  5. Bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease: background, evolution, and current concerns.
    Personal Author:
    Brown, P.; Will, R. G.; Bradley, R.; Asher, D. M.; Detwiler, L.;
    Published:
    2001 Jan-Feb
    Source:
    Emerg Infect Dis. 7(1):6-16.
    Description:
    The epidemic of bovine spongiform encephalopathy (BSE) in the United Kingdom, which began in 1986 and has affected nearly 200,000 cattle, is waning to a conclusion, but leaves in its wake an outbreak of human Creutzfeldt-Jakob disease, most probably ...
    File Type:
    Filetype[PDF - 129.36 KB]