Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid1301.060396
Personal Author:
Dietz, Klaus ; Raddatz, Günter ; Wallis, Jonathan ; Müller, Norbert ; Zerr, Inga ; ... More +
Dietz, Klaus ; Raddatz, Günter ; Wallis, Jonathan ; Müller, Norbert ; Zerr, Inga ; Duerr, Hans-Peter ; Lefèvre, Hans ; Seifried, Erhard ; Löwer, Johannes ; Less -
Description:
Variant Creutzfeldt-Jakob disease (vCJD) may be transmissible by blood. To prevent secondary transmission through blood components, several countries have started to exclude as donors persons who have received a blood transfusion. We investigated the effectiveness of this measure by using a dynamic age-structured model. It is the first such model based on epidemiologic data: 1) blood donor activities, 2) a case-control study on CJD, 3) age distribution of recipients, and 4) death of recipients of blood transfusions. The model predicts that an infection like vCJD, which has been introduced into the population by the alimentary route, could not become endemic by transfusion alone and that only <1% of cases would be avoided by excluding from blood donation those persons who have received a transfusion.
Subject:
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Adolescent
Adult
Aged
Biometry
Blood Donors
Blood Transfusion
Communicable Diseases
Creutzfeldt-Jakob Syndrome
Emerging
Endemic Diseases
Epidemiology
Humans
Incidence
Infection
Middle Aged
Models
Models, Biological
Prevalence
Research
Risk Assessment
Risk Factors
Theoretical
Variant Creutzfeldt-Jakob Disease
Blood Transfusion

Source:
Emerg Infect Dis. 13(1):89-96. ;
Document Type:
Journal Article ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:bc33c77a2453f2bdf1a8e8265e2d79ef17ea7a44cb181b0f5d36df1103178e5e
File Type:

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