Similar Biochemical Signatures and Prion Protein Genotypes in Atypical Scrapie and Nor98 Cases, France and Norway

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Arsac, Jean-Noël ; Andreoletti, Olivier ; Bilheude, Jean-Marc ; Lacroux, Caroline ; Benestad, Sylvie L. ; Baron, Thierry
• Description:
  Isolates of atypical scrapie recently identified in sheep and goats in France were compared with Nor98 isolates reported in Norway. Western blot methods for characterization of the protease-resistant prion protein showed that all these isolates shared a unique biochemical signature: 5 groups of bands, including a characteristic band of apparent low molecular weight (11 kDa). This pattern could originate from the presence of 3 different protease cleavage products, including the 11 kDa most likely cleaved at both N- and C-sides of the protein. Genetic data, which strongly suggested the higher susceptibility of AHQ and AF141RQ animals in French cases, resembled earlier data from Nor98 scrapie.
• Subjects:
  Alleles Animals Brain Stem Genotype Goat Diseases Goats Polymorphism, Genetic Prions Sheep
• Source:
  Emerg Infect Dis. 13(1):58-65.
• Document Type:
  Journal Article
• Place as Subject:
  France ; Norway
• Volume:
  13
• Issue:
  1
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:9cd0ca6e84f025a07e46b846c3b787a9bdd00ff016413ac4e0250da1cd60732c
• Download URL:
  https://stacks.cdc.gov/view/cdc/16305/cdc_16305_DS1.pdf
• File Type:
  [PDF - 311.07 KB ]