Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid1301.060393
Personal Author:
Arsac, Jean-Noël ; Andreoletti, Olivier ; Bilheude, Jean-Marc ; Lacroux, Caroline ; Benestad, Sylvie L. ; ... More +
Arsac, Jean-Noël ; Andreoletti, Olivier ; Bilheude, Jean-Marc ; Lacroux, Caroline ; Benestad, Sylvie L. ; Baron, Thierry Less -
Description:
Isolates of atypical scrapie recently identified in sheep and goats in France were compared with Nor98 isolates reported in Norway. Western blot methods for characterization of the protease-resistant prion protein showed that all these isolates shared a unique biochemical signature: 5 groups of bands, including a characteristic band of apparent low molecular weight (11 kDa). This pattern could originate from the presence of 3 different protease cleavage products, including the 11 kDa most likely cleaved at both N- and C-sides of the protein. Genetic data, which strongly suggested the higher susceptibility of AHQ and AF141RQ animals in French cases, resembled earlier data from Nor98 scrapie.
Subject:
[+]
Alleles
Animals
Brain Stem
Genotype
Goat Diseases
Goats
Polymorphism, Genetic
Prions
Sheep

Source:
Emerg Infect Dis. 13(1):58-65.
Document Type:
Journal Article
Place as Subject:
France ; Norway
France ; Norway Less -
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:9cd0ca6e84f025a07e46b846c3b787a9bdd00ff016413ac4e0250da1cd60732c
File Type:

Supporting Files

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