Antibody Response to Pneumocystis jirovecii
Published Date:Aug 2006
Source:Emerg Infect Dis. 12(8):1231-1237.
Keywords:Acquired Immune Deficiency Syndrome (AIDS)
AIDS-Related Opportunistic Infections
Enzyme-Linked Immunosorbent Assay
Enzyme-linked Immunosorbent Assay (ELISA)
First Episode Pneumocystosis
Human Immunodeficiency Virus (HIV)
Major Surface Glycoprotein (Msg)
Serum Antibody Responses
Description:We conducted a prospective pilot study of the serologic responses to overlapping recombinant fragments of the Pneumocystis jirovecii major surface glycoprotein (Msg) in HIV-infected patients with pneumonia due to P. jirovecii and other causes. Similar baseline geometric mean antibody levels to the fragments measured by an ELISA were found in both groups. Serum antibodies to MsgC in P. jirovecii patients rose to a peak level 3-4 weeks (p<0.001) after recovery from pneumocystosis; baseline CD4+ count > or =50 cells/microL and first episode of pneumocystosis were the principal host factors associated with this rise (both p<0.001). Thus, MsgC shows promise as a serologic reagent and should be tested further in clinical and epidemiologic studies.
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