Antibody Response to Pneumocystis jirovecii

Daly, Kieran R.; Huang, Laurence; Morris, Alison; Koch, Judy; Crothers, Kristina; Levin, Linda; Eiser, Shary; Satwah, Supriya; Zucchi, Patrizia; Walzer, Peter D.

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Antibody Response to Pneumocystis jirovecii

Aug 2006
By Daly, Kieran R. ; Huang, Laurence ; Morris, Alison ; ...
Source: Emerg Infect Dis. 12(8):1231-1237.

[PDF-227.71 KB]

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Daly, Kieran R. ; Huang, Laurence ; Morris, Alison ; Koch, Judy ; Crothers, Kristina ; ... More +

Daly, Kieran R. ; Huang, Laurence ; Morris, Alison ; Koch, Judy ; Crothers, Kristina ; Levin, Linda ; Eiser, Shary ; Satwah, Supriya ; Zucchi, Patrizia ; Walzer, Peter D. Less -
Description:

We conducted a prospective pilot study of the serologic responses to overlapping recombinant fragments of the Pneumocystis jirovecii major surface glycoprotein (Msg) in HIV-infected patients with pneumonia due to P. jirovecii and other causes. Similar baseline geometric mean antibody levels to the fragments measured by an ELISA were found in both groups. Serum antibodies to MsgC in P. jirovecii patients rose to a peak level 3-4 weeks (p<0.001) after recovery from pneumocystosis; baseline CD4+ count > or =50 cells/microL and first episode of pneumocystosis were the principal host factors associated with this rise (both p<0.001). Thus, MsgC shows promise as a serologic reagent and should be tested further in clinical and epidemiologic studies.
Subjects:

[+]

Acquired Immune Deficiency Syndrome (AIDS) Adult AIDS-Related Opportunistic Infections Antibodies, Fungal CD4+ Cells Enzyme-Linked Immunosorbent Assay Enzyme-linked Immunosorbent Assay (ELISA) Female First Episode Pneumocystosis Fungal Proteins HIV Infections Human Immunodeficiency Virus (HIV) Humans Major Surface Glycoprotein (Msg) Male Membrane Glycoproteins Middle Aged Pneumocystis Jirovecii Pneumocystis Pneumonia Pneumonia, Pneumocystis Recombinant Antigens Research Serum Antibody Responses
Source:

Emerg Infect Dis. 12(8):1231-1237.
Document Type:

Journal Article
Volume:

12
Issue:

8
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:eaa23943d47e6ba5f4cb5bb7926d5492cc49dc876937634121a0e40d875bd4b9
Download URL:

https://stacks.cdc.gov/view/cdc/16251/cdc_16251_DS1.pdf
File Type:

	06-0230-F.gif	gif
	06-0230-F.jpg	jpeg
	06-0230.nxml	txt
	license.txt	txt

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