Impact of Chlorpyrifos Exposure on Lung Function in Egyptian Adolescent Agriculture Workers

Mendez, Ernesto E.; Davis, Jonathan; Bonner, Matthew R.; Abdel Rasoul, Gaafar M.; Ismail, Ahmed A.; Hendy, Olfat M.; Olson, James R.; Rohlman, Diane S.

doi:10.1080/19338244.2024.2374582

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Impact of Chlorpyrifos Exposure on Lung Function in Egyptian Adolescent Agriculture Workers

2024
By Mendez, Ernesto E. ; Davis, Jonathan ; Bonner, Matthew R. ; ...
Source: Arch Environ Occup Health. 79(3-4):121-129

Public Access Version Available on: July 12, 2025, 12:00 AM

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English

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Details:

Alternative Title:

Arch Environ Occup Health
Personal Author:

Mendez, Ernesto E. ; Davis, Jonathan ; Bonner, Matthew R. ; Abdel Rasoul, Gaafar M. ; Ismail, Ahmed A. ; ... More +

Mendez, Ernesto E. ; Davis, Jonathan ; Bonner, Matthew R. ; Abdel Rasoul, Gaafar M. ; Ismail, Ahmed A. ; Hendy, Olfat M. ; Olson, James R. ; Rohlman, Diane S. Less -
Description:

Chlorpyrifos (CPF) is a widely used organophosphate insecticide that has been linked to detrimental health effects that range from neurological impacts to respiratory disease. The objective of this study was to assess respiratory symptoms associated with CPF exposure throughout the application season. Urine samples were collected from Egyptian adolescent applicators (| = 206) and non-applicators (| = 72) to assess 3,5,6-trichloro-2-pyridinol (TCPy), a biomarker for CPF exposure, along with spirometry measures to determine lung ventilatory function. Samples were collected over 7 months in 2016. Logistic regression was used to model the odds of reporting wheeze symptoms based on urinary TCPy concentrations while controlling for age and smoking in the household. Ordinal multinomial logistic regression was used to model the percent reference for forced expiratory volume in one second (rFEV|) based on urinary TCPy concentration (µg/g creatinine). Wheezing increased with increasing pesticide exposure (OR = 1.74 (1.32 - 2.31)). There was no statistically significant relationship between rFEV| and TCPy concentration. Efforts to reduce pesticide exposure should be implemented to prevent the potential onset or exacerbation of any linked respiratory complications in adolescents.
Subjects:

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Adolescent Biomarkers Chlorpyrifos Egypt Farmers Female Humans Insecticides Lung Male Occupational Exposure Pyridones Respiratory Sounds
Keywords:

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Pesticides Respiratory Health Spirometry
Source:

Arch Environ Occup Health. 79(3-4):121-129
Pubmed ID:

38993119
Pubmed Central ID:

PMC11392629
Document Type:

Journal Article
Funding:

R01 ES022163/ES/NIEHS NIH HHSUnited States/ ; R49 CE003095/CE/NCIPC CDC HHSUnited States/ ; T42 OH008491/OH/NIOSH CDC HHSUnited States/ ; U19 OH008868/OH/NIOSH CDC HHSUnited States/

R01 ES022163/ES/NIEHS NIH HHSUnited States/ ; R49 CE003095/CE/NCIPC CDC HHSUnited States/ ; T42 OH008491/OH/NIOSH CDC HHSUnited States/ ; U19 OH008868/OH/NIOSH CDC HHSUnited States/ Less -
Volume:

79
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha-512:4b76ac6faba90417cddc604c0998db36a128ed436d20bc1531eb138070d1a10b637270e830482a9621293ce59263d77c36100f9a55c3bc3b106e38e7dd3202c4
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