Impact of Chlorpyrifos Exposure on Lung Function in Egyptian Adolescent Agriculture Workers

Details

• Personal Author:
  Abdel Rasoul GM ; Bonner MR ; Davis J ; Hendy OM ; Ismail AA ; Mendez EE ; Olson JR ; Rohlman DS
• Description:
  Chlorpyrifos (CPF) is a widely used organophosphate insecticide that has been linked to detrimental health effects that range from neurological impacts to respiratory disease. The objective of this study was to assess respiratory symptoms associated with CPF exposure throughout the application season. Urine samples were collected from Egyptian adolescent applicators (n = 206) and non-applicators (n = 72) to assess 3,5,6-trichloro-2-pyridinol (TCPy), a biomarker for CPF exposure, along with spirometry measures to determine lung ventilatory function. Samples were collected over 7 months in 2016. Logistic regression was used to model the odds of reporting wheeze symptoms based on urinary TCPy concentrations while controlling for age and smoking in the household. Ordinal multinomial logistic regression was used to model the percent reference for forced expiratory volume in one second (rFEV1) based on urinary TCPy concentration (µg/g creatinine). Wheezing increased with increasing pesticide exposure (OR = 1.74 (1.32 - 2.31)). There was no statistically significant relationship between rFEV1 and TCPy concentration. Efforts to reduce pesticide exposure should be implemented to prevent the potential onset or exacerbation of any linked respiratory complications in adolescents. [Description provided by NIOSH]
• Subjects:
  Adolescent Biomarkers Insecticides Lung Occupational Health Respiratory Function Tests Respiratory System Safety
• Keywords:
  Adolescents Author Keywords: Adolescent Chlorpyrifos Lung Function Occupational Exposure Organophosphorus Insecticides Pest Control Pesticides Respiratory Health Spirometry
• ISSN:
  1933-8244
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Iowa ; New York ; OSHA Region 2 ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  121-129
• Volume:
  49
• Issue:
  3
• NIOSHTIC Number:
  nn:20070119
• Citation:
  Arch Environ Occup Health 2024 Apr; 79(3-4):121-129
• Contact Point Address:
  Diane S. Rohlman, Department of Occupational and Environmental Health, University of Iowa, Iowa City, Iowa, USA
• Email:
  diane-rohlman@uiowa.edu
• CAS Registry Number:
  Chlorpyrifos (CAS RN 2921-88-2)
• Federal Fiscal Year:
  2024
• Performing Organization:
  University of Iowa
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Archives of Environmental & Occupational Health
• End Date:
  20290630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:be29129bccef97f0bf551a1f4294491277057e564e509aef53f37c3fc5133f31435518979466d42f3bf0827ce71713be3b679b077efb070fd1bd0754217cdfdc
• Download URL:
  https://stacks.cdc.gov/view/cdc/208404/cdc_208404_DS1.pdf
• File Type:
  [PDF - 993.49 KB ]