Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Metlay, Joshua P. ; Fishman, Neil O. ; Joffe, Marshall M. ; Kallan, Michael J. ; Chittams, Jesse L. ; ... More +
Metlay, Joshua P. ; Fishman, Neil O. ; Joffe, Marshall M. ; Kallan, Michael J. ; Chittams, Jesse L. ; Edelstein, Paul H. Less -
Description:
We conducted a case-control study of adults with bacteremic pneumococcal pneumonia to identify factors associated with macrolide resistance. Study participants were identified through population-based surveillance in a 5-county region surrounding Philadelphia. Forty-three hospitals contributed 444 patients, who were interviewed by telephone regarding potential risk factors. In multivariable analyses, prior exposure to a macrolide antimicrobial agent (odds ratio [OR] 2.8), prior flu vaccination (OR 2.0), and Hispanic ethnicity (OR 4.1) were independently associated with an increased probability of macrolide resistance, and a history of stroke was independently associated with a decreased probability of macrolide resistance (OR 0.2). Fifty-five percent of patients with macrolide-resistant infections reported no antimicrobial drug exposure in the preceding 6 months. Among patients who reported taking antimicrobial agents in the 6 months preceding infection, failure to complete the course of prescribed drugs was associated with an increased probability of macrolide resistance (OR 3.4).
Subject:
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Adolescent
Adult
Aged
Anti-Bacterial Agents
Bacteremia
Case-Control Studies
Drug Resistance, Bacterial
Female
Hospitalization
Humans
Interviews As Topic
Macrolides
Male
Middle Aged
Pneumonia, Pneumococcal
Population Surveillance
Risk Factors

Source:
Emerg Infect Dis. 12(8):1223-1230.
Document Type:
Journal Article
Place as Subject:
Pennsylvania
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:d1e269d73266b1e624a353483c4d254e6558f043f77a01d37264144f1f8db0d8
File Type:

Supporting Files

• 	06-0017-F.gif	gif
  	06-0017-F.jpg	jpeg
  	06-0017.nxml	txt
  	license.txt	txt

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