Macrolide Resistance in Adults with Bacteremic Pneumococcal Pneumonia

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Metlay, Joshua P. ; Fishman, Neil O. ; Joffe, Marshall M. ; Kallan, Michael J. ; Chittams, Jesse L. ; Edelstein, Paul H.
• Description:
  We conducted a case-control study of adults with bacteremic pneumococcal pneumonia to identify factors associated with macrolide resistance. Study participants were identified through population-based surveillance in a 5-county region surrounding Philadelphia. Forty-three hospitals contributed 444 patients, who were interviewed by telephone regarding potential risk factors. In multivariable analyses, prior exposure to a macrolide antimicrobial agent (odds ratio [OR] 2.8), prior flu vaccination (OR 2.0), and Hispanic ethnicity (OR 4.1) were independently associated with an increased probability of macrolide resistance, and a history of stroke was independently associated with a decreased probability of macrolide resistance (OR 0.2). Fifty-five percent of patients with macrolide-resistant infections reported no antimicrobial drug exposure in the preceding 6 months. Among patients who reported taking antimicrobial agents in the 6 months preceding infection, failure to complete the course of prescribed drugs was associated with an increased probability of macrolide resistance (OR 3.4).
• Subjects:
  Adolescent Adult Aged Anti-Bacterial Agents Bacteremia Case-Control Studies Drug Resistance, Bacterial Female Hospitalization Humans Interviews As Topic Macrolides Male Middle Aged Pneumonia, Pneumococcal Population Surveillance Risk Factors

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• Source:
  Emerg Infect Dis. 12(8):1223-1230.
• Document Type:
  Journal Article
• Place as Subject:
  Pennsylvania
• Volume:
  12
• Issue:
  8
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:d1e269d73266b1e624a353483c4d254e6558f043f77a01d37264144f1f8db0d8
• Download URL:
  https://stacks.cdc.gov/view/cdc/16200/cdc_16200_DS1.pdf
• File Type:
  [PDF - 176.65 KB ]