Neisseria meningitidis Sequence Type and Risk for Death, Iceland

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Gottfreðsson, Magnús ; Diggle, Mathew A. ; Lawrie, David I. ; Erlendsdóttir, Helga ; Harðardóttir, Hjördís ; Kristinsson, Karl G. ; Clarke, Stuart C.
• Description:
  Invasive meningococcal infections are hyperendemic in Iceland, a relatively isolated country in the mid-Atlantic. We performed a nationwide study on all viable meningococcal strains (N = 362) from 1977 to 2004. We analyzed the association of patient's age and sex, meningococcal serogroups, and sequence types (STs) with outcomes. Overall, 59 different STs were identified, 19 of which were unique to Iceland. The most common STs were 32 (24.6%), 11 (19.9%), and 10 (10.2%). The unique ST-3492 ranked fourth (7.7%). The most common serogroups were B (56.4%), C (39.8%), and A (2.2%). Age (p < 0.001) and infection with a unique ST (p = 0.011) were independently associated with increased death rates, whereas isolation of meningococci from cerebrospinal fluid only was associated with lower death rates (p = 0.046). This study shows evolutionary trends of meningococcal isolates in a relatively isolated community and highlights an association between unique STs and poor outcome.
• Subjects:
  Adolescent Adult Age And Infection With Unique Sequence Type Were Associated With Risk For Death Aging Anti-Bacterial Agents Child Child, Preschool Drug Resistance, Bacterial Epidemiology Female Humans Iceland Infant Longitudinal Studies Male Meningitis Meningococcal Disease Meningococcal Infections Mortality Multilocus Sequence Typing (MLST) Neisseria Meningitidis Phylogeny Research Risk Factors

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• Source:
  Emerg Infect Dis. 12(7):1066-1073.
• Document Type:
  Journal Article
• Place as Subject:
  Iceland
• Volume:
  12
• Issue:
  7
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:6cc04df01b78d80f370c23dbe03f68bb85fa7ceb9e4ddd50f95948c27fb8cc3a
• Download URL:
  https://stacks.cdc.gov/view/cdc/16185/cdc_16185_DS1.pdf
• File Type:
  [PDF - 269.66 KB ]