Haemophilus influenzae Type b Reemergence after Combination Immunization

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Johnson, Nik G. ; Ruggeberg, Jens U. ; Balfour, Gail F. ; Lee, Y. Chen ; Liddy, Helen ; Irving, Diane ; Sheldon, Joanna ; Slack, Mary P.E. ; Pollard, Andrew J. ; Heath, Paul T.
• Description:
  An increase in Haemophilus influenzae type b (Hib) in British children has been linked to the widespread use of a diphtheria/tetanus/acellular pertussis combination vaccine (DTaP-Hib). We measured anti-polyribosyl-ribitol phosphate antibody concentration and avidity before and after a Hib booster in 176 children 2-4 years of age who had received 3 doses of DTP-Hib (either DT whole cell pertussis-Hib or DTaP-Hib) combination vaccine in infancy. We also measured pharyngeal carriage of Hib. Antibody concentrations before and avidity indices after vaccination were low (geometric mean concentration 0.46 mug/mL, 95% confidence interval CI 0.36-0.58; geometric mean avidity index 0.16, 95% CI 0.14-0.18) and inversely related to the number of previous doses of DTaP-Hib (p = 0.02 and p<0.001, respectively). Hib was found in 2.1% (95% CI 0.7%-6.0%) of study participants. Our data support an association between DTaP-Hib vaccine combinations and clinical Hib disease through an effect on antibody concentration and avidity.
• Subjects:
  • Research
  • Haemophilus influenzae type b
  • haemophilus vaccines
  • antibody avidity
  • diphtheria-tetanus-acellular pertussis vaccines
  • antibodies
  • carrier state/epidemiology
  • research
  • Antibodies, Viral
  • Antibody Affinity
  More +
• Source:
  Emerg Infect Dis. 12(6):937-941.
• Document Type:
  Journal Article
• Volume:
  12
• Issue:
  6
• Download URL:
  https://stacks.cdc.gov/view/cdc/16147/cdc_16147_DS1.pdf
• File Type:
  [PDF - 93.79 KB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:25c0bd53614080d2d5b3000d3567304d4f749f4146368bfca73a3d5e548b489d