Haemophilus influenzae Type b Reemergence after Combination Immunization

Johnson, Nik G.; Ruggeberg, Jens U.; Balfour, Gail F.; Lee, Y. Chen; Liddy, Helen; Irving, Diane; Sheldon, Joanna; Slack, Mary P.E.; Pollard, Andrew J.; Heath, Paul T.

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Haemophilus influenzae Type b Reemergence after Combination Immunization

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Jun 2006
By Johnson, Nik G. ; Ruggeberg, Jens U. ; Balfour, Gail F. ; ...

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Alternative Title:

Emerg Infect Dis
Personal Author:

Johnson, Nik G. ; Ruggeberg, Jens U. ; Balfour, Gail F. ; Lee, Y. Chen ; Liddy, Helen ; Irving, Diane ; Sheldon, Joanna ; Slack, Mary P.E. ; Pollard, Andrew J. ; Heath, Paul T.
Description:

An increase in Haemophilus influenzae type b (Hib) in British children has been linked to the widespread use of a diphtheria/tetanus/acellular pertussis combination vaccine (DTaP-Hib). We measured anti-polyribosyl-ribitol phosphate antibody concentration and avidity before and after a Hib booster in 176 children 2-4 years of age who had received 3 doses of DTP-Hib (either DT whole cell pertussis-Hib or DTaP-Hib) combination vaccine in infancy. We also measured pharyngeal carriage of Hib. Antibody concentrations before and avidity indices after vaccination were low (geometric mean concentration 0.46 mug/mL, 95% confidence interval [CI] 0.36-0.58; geometric mean avidity index 0.16, 95% CI 0.14-0.18) and inversely related to the number of previous doses of DTaP-Hib (p = 0.02 and p<0.001, respectively). Hib was found in 2.1% (95% CI 0.7%-6.0%) of study participants. Our data support an association between DTaP-Hib vaccine combinations and clinical Hib disease through an effect on antibody concentration and avidity.
Subjects:

Antibodies Antibodies, Viral Antibody Affinity Antibody Avidity Bacterial Capsules Carrier State/epidemiology Child, Preschool Diphtheria-tetanus-acellular Pertussis Vaccines Great Britain Haemophilus Infections Haemophilus Influenzae Type B Haemophilus Vaccines Humans Immunization Pharynx Polysaccharides, Bacterial Research Statistics, Nonparametric Vaccines, Conjugate
Source:

Emerg Infect Dis. 12(6):937-941.
Document Type:

Journal Article
Volume:

12
Issue:

6
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:25c0bd53614080d2d5b3000d3567304d4f749f4146368bfca73a3d5e548b489d
Download URL:

https://stacks.cdc.gov/view/cdc/16147/cdc_16147_DS1.pdf
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[PDF - 93.79 KB ]

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