Influenza, Campylobacter and Mycoplasma Infections, and Hospital Admissions for Guillain-Barré Syndrome, England

Tam, Clarence C.; O’Brien, Sarah J.; Rodrigues, Laura C.

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Influenza, Campylobacter and Mycoplasma Infections, and Hospital Admissions for Guillain-Barré Syndrome, England

Supporting Files Public Domain

Dec 2006
By Tam, Clarence C. ; O’Brien, Sarah J. ; Rodrigues, Laura C.

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Tam, Clarence C. ; O’Brien, Sarah J. ; Rodrigues, Laura C.
Description:

Guillain-Barré syndrome (GBS) is the most common cause of acute flaccid paralysis in polio-free regions. Considerable evidence links Campylobacter infection with GBS, but evidence that implicates other pathogens as triggers remains scarce. We conducted a time-series analysis to investigate short-term correlations between weekly laboratory-confirmed reports of putative triggering pathogens and weekly hospitalizations for GBS in England from 1993 through 2002. We found a positive association between the numbers of reports of laboratory-confirmed influenza A in any given week and GBS hospitalizations in the same week. Different pathogens may trigger GBS in persons of different ages; among those <35 years, numbers of weekly GBS hospitalizations were associated with weekly Campylobacter and Mycoplasma pneumoniae reports, whereas among those >35 years, positive associations were with influenza. Further studies should estimate the relative contribution of different pathogens to GBS incidence, overall and by age group, and determine whether influenza is a real trigger for GBS or a marker for influenza vaccination.
Subjects:

Adult Aged Age Factors Campylobacter Campylobacter Infections Cytomegalovirus England Epstein-Barr Virus Female Guillain-Barre Syndrome Guillain-Barré Syndrome Haemophilus Influenzae Hospitalization Humans Influenza Influenza, Human Male Middle Aged Mycoplasma Pneumoniae Orthomyxoviridae Pneumonia, Mycoplasma Polyradiculoneuropathy Regression Analysis Research Seasons Sequelae Time-series Analysis
Source:

Emerg Infect Dis. 12(12):1880-1887.
Document Type:

Journal Article
Volume:

12
Issue:

12
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:54d20c8d1e024bca5a3042e067b40d760a7f0b0e2c92611f4a34e7ce317704bb
Download URL:

https://stacks.cdc.gov/view/cdc/16061/cdc_16061_DS1.pdf
File Type:

[PDF - 253.78 KB ]

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