Influenza, Campylobacter and Mycoplasma Infections, and Hospital Admissions for Guillain-Barré Syndrome, England

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Tam, Clarence C. ; O’Brien, Sarah J. ; Rodrigues, Laura C.
• Description:
  Guillain-Barré syndrome (GBS) is the most common cause of acute flaccid paralysis in polio-free regions. Considerable evidence links Campylobacter infection with GBS, but evidence that implicates other pathogens as triggers remains scarce. We conducted a time-series analysis to investigate short-term correlations between weekly laboratory-confirmed reports of putative triggering pathogens and weekly hospitalizations for GBS in England from 1993 through 2002. We found a positive association between the numbers of reports of laboratory-confirmed influenza A in any given week and GBS hospitalizations in the same week. Different pathogens may trigger GBS in persons of different ages; among those <35 years, numbers of weekly GBS hospitalizations were associated with weekly Campylobacter and Mycoplasma pneumoniae reports, whereas among those >35 years, positive associations were with influenza. Further studies should estimate the relative contribution of different pathogens to GBS incidence, overall and by age group, and determine whether influenza is a real trigger for GBS or a marker for influenza vaccination.
• Subjects:
  • Research
  • Guillain-Barré syndrome
  • Campylobacter
  • influenza
  • Mycoplasma pneumoniae
  • Haemophilus influenzae
  • cytomegalovirus
  • Epstein-Barr virus
  • sequelae
  • polyradiculoneuropathy
  More +
• Source:
  Emerg Infect Dis. 12(12):1880-1887.
• Document Type:
  Journal Article
• Volume:
  12
• Issue:
  12
• Download URL:
  https://stacks.cdc.gov/view/cdc/16061/cdc_16061_DS1.pdf
• File Type:
  [PDF - 253.78 KB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:54d20c8d1e024bca5a3042e067b40d760a7f0b0e2c92611f4a34e7ce317704bb