Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Tam, Clarence C. ; O’Brien, Sarah J. ; Rodrigues, Laura C.
Tam, Clarence C. ; O’Brien, Sarah J. ; Rodrigues, Laura C. Less -
Description:
Guillain-Barré syndrome (GBS) is the most common cause of acute flaccid paralysis in polio-free regions. Considerable evidence links Campylobacter infection with GBS, but evidence that implicates other pathogens as triggers remains scarce. We conducted a time-series analysis to investigate short-term correlations between weekly laboratory-confirmed reports of putative triggering pathogens and weekly hospitalizations for GBS in England from 1993 through 2002. We found a positive association between the numbers of reports of laboratory-confirmed influenza A in any given week and GBS hospitalizations in the same week. Different pathogens may trigger GBS in persons of different ages; among those <35 years, numbers of weekly GBS hospitalizations were associated with weekly Campylobacter and Mycoplasma pneumoniae reports, whereas among those >35 years, positive associations were with influenza. Further studies should estimate the relative contribution of different pathogens to GBS incidence, overall and by age group, and determine whether influenza is a real trigger for GBS or a marker for influenza vaccination.
Subject:
[+]
Adult
Aged
Age Factors
Campylobacter
Campylobacter Infections
Cytomegalovirus
England
Epstein-Barr Virus
Female
Guillain-Barre Syndrome
Guillain-Barré Syndrome
Haemophilus Influenzae
Hospitalization
Humans
Influenza
Influenza, Human
Male
Middle Aged
Mycoplasma Pneumoniae
Orthomyxoviridae
Pneumonia, Mycoplasma
Polyradiculoneuropathy
Regression Analysis
Research
Seasons
Sequelae
Time-series Analysis

Source:
Emerg Infect Dis. 12(12):1880-1887.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:54d20c8d1e024bca5a3042e067b40d760a7f0b0e2c92611f4a34e7ce317704bb
File Type:

Supporting Files

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