Population Incidence of Guillain-Barré Syndrome: A Systematic Review and Meta-Analysis

Details

• Alternative Title:
  Neuroepidemiology
• Personal Author:
  Sejvar, James J. ; Baughman, Andrew L. ; Wise, Matthew ; Morgan, Oliver W.
• Description:
  Population incidence of Guillain-Barré syndrome (GBS) is required to assess changes in GBS epidemiology, but published estimates of GBS incidence vary greatly depending on case ascertainment, definitions, and sample size. We performed a meta-analysis of articles on GBS incidence by searching Medline (1966-2009), Embase (1988-2009), Cinahl (1981-2009) and CABI (1973-2009) as well as article bibliographies. We included studies from North America and Europe with at least 20 cases, and used population-based data, subject matter experts to confirm GBS diagnosis, and an accepted GBS case definition. With these data, we fitted a random-effects negative binomial regression model to estimate age-specific GBS incidence. Of 1,683 nonduplicate citations, 16 met the inclusion criteria, which produced 1,643 cases and 152.7 million person-years of follow-up. GBS incidence increased by 20% for every 10-year increase in age; the risk of GBS was higher for males than females. The regression equation for calculating the average GBS rate per 100,000 person-years as a function of age in years was exp[-12.0771 + 0.01813(age in years)] × 100,000. Our findings provide a robust estimate of background GBS incidence in Western countries. Our regression model may be used in comparable populations to estimate the background age-specific rate of GBS incidence for future studies.
• Subjects:
  Age Factors Animals Guillain-Barre Syndrome Humans Incidence Population Surveillance Risk Factors
• Keywords:
  Guillain-Barré Syndrome Guillain-Barré Syndrome, Incidence Guillain-Barré Syndrome, Meta-analysis
• Source:
  Neuroepidemiology. 36(2):123-133
• Pubmed ID:
  21422765
• Pubmed Central ID:
  PMC5703046
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  36
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:fe54440004b0dd4579bf8d5f3ac31bb26fa20d6b9959e89a4df79b732711b3398785552e492a372e9502e1af2471847709c9cfe2e63de3e909d17c2df40ccc36
• Download URL:
  https://stacks.cdc.gov/view/cdc/50394/cdc_50394_DS1.pdf
• File Type:
  [PDF - 1.26 MB ]