Neighborhood Deprivation and Neural Tube Defects

Details

• Alternative Title:
  Epidemiology
• Personal Author:
  Evans, Shannon Pruitt ; Ailes, Elizabeth C. ; Kramer, Michael R. ; Shumate, Charles J. ; Reefhuis, Jennita ; Insaf, Tabassum Z. ; Yazdy, Mahsa M. ; Carmichael, Suzan L. ; Romitti, Paul A. ; Feldkamp, Marcia L. ; Neo, Dayna T. ; Nembhard, Wendy N. ; Shaw, Gary M. ; Palmi, Elizabeth ; Gilboa, Suzanne M.
• Corporate Authors:
  National Birth Defects Prevention Study
• Description:
  Background:
  
  Individual measures of socioeconomic status (SES) have been associated with an increased risk of neural tube defects (NTDs); however, the association between neighborhood SES and NTD risk is unknown. Using data from the National Birth Defects Prevention Study (NBDPS) from 1997 to 2011, we investigated the association between measures of census tract SES and NTD risk.
  
  Methods:
  
  The study population included 10,028 controls and 1829 NTD cases. We linked maternal addresses to census tract SES measures and used these measures to calculate the neighborhood deprivation index. We used generalized estimating equations to calculate adjusted odds ratios (aORs) and 95% confidence intervals (CIs) estimating the impact of quartiles of census tract deprivation on NTDs adjusting for maternal race–ethnicity, maternal education, and maternal age at delivery.
  
  Results:
  
  Quartiles of higher neighborhood deprivation were associated with NTDs when compared with the least deprived quartile (Q2: aOR = 1.2; 95% CI = 1.0, 1.4; Q3: aOR = 1.3, 95% CI = 1.1, 1.5; Q4 (highest): aOR = 1.2; 95% CI = 1.0, 1.4). Results for spina bifida were similar; however, estimates for anencephaly and encephalocele were attenuated. Associations differed by maternal race–ethnicity.
  
  Conclusions:
  
  Our findings suggest that residing in a census tract with more socioeconomic deprivation is associated with an increased risk for NTDs, specifically spina bifida.
  
  
• Subjects:
  Educational Status Ethnicity Female Humans Maternal Age Neural Tube Defects Odds Ratio
• Keywords:
  Anencephaly Encephalocele Neighborhood Deprivation Neural Tube Defects Socioeconomic Status Spina Bifida
• Source:
  Epidemiology. 34(6):774-785
• Pubmed ID:
  37757869
• Pubmed Central ID:
  PMC10928547
• Document Type:
  Journal Article
• Funding:
  U01 DD001304/DD/NCBDD CDC HHSUnited States/ ; U01 DD001224/DD/NCBDD CDC HHSUnited States/ ; U01 DD001227/DD/NCBDD CDC HHSUnited States/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ ; U01 DD001032/DD/NCBDD CDC HHSUnited States/ ; U01 DD001037/DD/NCBDD CDC HHSUnited States/ ; CDP 13-003/HX/HSRD VAUnited States/ ; P30 ES005605/ES/NIEHS NIH HHSUnited States/ ; EP-D-18-001/EPA/EPAUnited States/ ; U01 DD001300/DD/NCBDD CDC HHSUnited States/
• Volume:
  34
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:6396f2064c517625dc7471e99889feb5ef98b3467526e497befb8d474dc1dacb8afd277a331f5477e6eb79d5e5a5cc31bedc0f1ab64e46b950366c04f1a2eb17
• Download URL:
  https://stacks.cdc.gov/view/cdc/151675/cdc_151675_DS1.pdf
• File Type:
  [PDF - 613.63 KB ]