Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Korenromp, Eline L. ; Williams, Brian G. ; de Vlas, Sake J. ; Gouws, Eleanor ; Gilks, Charles F. ; ... More +
Korenromp, Eline L. ; Williams, Brian G. ; de Vlas, Sake J. ; Gouws, Eleanor ; Gilks, Charles F. ; Ghys, Peter D. ; Nahlen, Bernard L. Less -
Description:
We assessed the impact of HIV-1 on malaria in the sub-Saharan African population. Relative risks for malaria in HIV-infected persons, derived from literature review, were applied to the HIV-infected population in each country, by age group, stratum of CD4 cell count, and urban versus rural residence. Distributions of CD4 counts among HIV-infected persons were modeled assuming a linear decline in CD4 after seroconversion. Averaged across 41 countries, the impact of HIV-1 was limited (although quantitatively uncertain) because of the different geographic distributions and contrasting age patterns of the 2 diseases. However, in Botswana, Zimbabwe, Swaziland, South Africa, and Namibia, the incidence of clinical malaria increased by < or =28% (95% confidence interval [CI] 14%-47%) and death increased by < or =114% (95% CI 37%-188%). These effects were due to high HIV-1 prevalence in rural areas and the locally unstable nature of malaria transmission that results in a high proportion of adult cases.
Subjects:
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Adolescent Adult Age Distribution Aids-Related Opportunistic Infections Cd4 Lymphocyte Count Child Child, Preschool Communicable Diseases, Emerging Hiv-1 Humans Incidence Malaria Rural Health Sentinel Surveillance Urban Health
Source:
Emerg Infect Dis. 11(9):1410-1419.
Document Type:
Journal Article
Place as Subject:
Africa South of the Sahara
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:aa261ca29e88691a53a80d975d5bf7096e7aa7f75736e4e82262697b9dd0bab1
Download URL:
https://stacks.cdc.gov/view/cdc/15885/cdc_15885_DS1.pdf
File Type:

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