Malaria Attributable to the HIV-1 Epidemic, Sub-Saharan Africa

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Korenromp, Eline L. ; Williams, Brian G. ; de Vlas, Sake J. ; Gouws, Eleanor ; Gilks, Charles F. ; Ghys, Peter D. ; Nahlen, Bernard L.
• Description:
  We assessed the impact of HIV-1 on malaria in the sub-Saharan African population. Relative risks for malaria in HIV-infected persons, derived from literature review, were applied to the HIV-infected population in each country, by age group, stratum of CD4 cell count, and urban versus rural residence. Distributions of CD4 counts among HIV-infected persons were modeled assuming a linear decline in CD4 after seroconversion. Averaged across 41 countries, the impact of HIV-1 was limited (although quantitatively uncertain) because of the different geographic distributions and contrasting age patterns of the 2 diseases. However, in Botswana, Zimbabwe, Swaziland, South Africa, and Namibia, the incidence of clinical malaria increased by < or =28% (95% confidence interval [CI] 14%-47%) and death increased by < or =114% (95% CI 37%-188%). These effects were due to high HIV-1 prevalence in rural areas and the locally unstable nature of malaria transmission that results in a high proportion of adult cases.
• Subjects:
  Adolescent Adult Age Distribution Aids-Related Opportunistic Infections Cd4 Lymphocyte Count Child Child, Preschool Communicable Diseases, Emerging Hiv-1 Humans Incidence Malaria Rural Health Sentinel Surveillance Urban Health

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• Source:
  Emerg Infect Dis. 11(9):1410-1419.
• Document Type:
  Journal Article
• Place as Subject:
  Africa South of the Sahara
• Volume:
  11
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:aa261ca29e88691a53a80d975d5bf7096e7aa7f75736e4e82262697b9dd0bab1
• Download URL:
  https://stacks.cdc.gov/view/cdc/15885/cdc_15885_DS1.pdf
• File Type:
  [PDF - 400.57 KB ]