Malaria Attributable to the HIV-1 Epidemic, Sub-Saharan Africa
Published Date:Sep 2005
Source:Emerg Infect Dis. 11(9):1410-1419.
Africa South Of The Sahara
AIDS-Related Opportunistic Infections
CD4 Lymphocyte Count
Communicable Diseases, Emerging
Prevention And Control
Description:We assessed the impact of HIV-1 on malaria in the sub-Saharan African population. Relative risks for malaria in HIV-infected persons, derived from literature review, were applied to the HIV-infected population in each country, by age group, stratum of CD4 cell count, and urban versus rural residence. Distributions of CD4 counts among HIV-infected persons were modeled assuming a linear decline in CD4 after seroconversion. Averaged across 41 countries, the impact of HIV-1 was limited (although quantitatively uncertain) because of the different geographic distributions and contrasting age patterns of the 2 diseases. However, in Botswana, Zimbabwe, Swaziland, South Africa, and Namibia, the incidence of clinical malaria increased by < or =28% (95% confidence interval [CI] 14%-47%) and death increased by < or =114% (95% CI 37%-188%). These effects were due to high HIV-1 prevalence in rural areas and the locally unstable nature of malaria transmission that results in a high proportion of adult cases.
image/gif image/jpeg image/gif image/jpeg image/gif image/jpeg image/jpeg image/jpeg image/jpeg image/jpeg image/jpeg image/jpeg image/jpeg image/jpeg text/plain text/plain
You May Also Like: