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Factors associated with viral suppression among adults living with HIV on antiretroviral therapy in Nigeria: Analysis of a population-based survey, 2018
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7 2023
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Source: HIV Med. 24(7):827-837
[PDF-256.27 KB]
Details:
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Alternative Title:HIV Med
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Personal Author:
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Description:Objective:
Viral load suppression (VLS) is critical in reducing morbidity and mortality associated with HIV as well as minimizing the likelihood of HIV transmission to uninfected individuals. The objective of this study was to identify factors associated with VLS among people living with HIV (PLWH) on antiretroviral (ARVs) therapy in a population-based survey to inform HIV program strategies in Nigeria.
Design and methods:
Adult participants,15–64 years old, from the 2018 Nigeria HIV/AIDS Indicator and Impact Survey (NAIIS) who self-reported to be a PLWH or had detectable ARVs were analyzed to examine factors associated with VLS. NAIIS measured HIV prevalence, viral load, HIV incidence, HIV drug resistance, ARV, and hepatitis B among PLWH.
Results:
Of 1,322 participants, 949 (71.8%) were women and 1,305 (98.7%) had detectable ARVs. The median age was 31 (interquartile range [IQR]: 39 – 48) years. Weighted prevalence of VLS was 80.6%. Compared to participants with detectable ARVs, those with undetected ARVs in their blood specimens had lower odds of VLS (adjusted odds ratio [aOR] = 0.24; 95% CI, 0.08–0.64). Those with hepatitis B infection (aOR = 0.29; 95% CI, 0.20–0.58) and non-nucleoside reverse transcriptase inhibitor-based regimen (aOR = 0.34; 95% CI, 0.12–1.01) were also associated with lower odds of VLS. However, older individuals, (45–54 vs. 15–24 years) had increased odds of VLS (aOR = 2.81; 95% CI, 1.14 – 6.90).
Conclusion:
Young individuals and those with undetectable ARVs were less likely to be virally suppressed. Targeted interventions focusing on young individuals and improved adherence to medication are needed to achieve the 95-95-95 goals, critical to HIV epidemic control. The study also confirms the superiority of protease inhibitor-based regimen for ARV treatment.
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Pubmed ID:36945183
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Pubmed Central ID:PMC11195444
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Volume:24
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Issue:7
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