Details:

Alternative Title:
Int J STD AIDS
Personal Author:
Parrish, Deidra D. ; Blevins, Meridith ; Megazzini, Karen M. ; Shepherd, Bryan E. ; Mohammed, Mukhtar Y. ; ... More +
Parrish, Deidra D. ; Blevins, Meridith ; Megazzini, Karen M. ; Shepherd, Bryan E. ; Mohammed, Mukhtar Y. ; Wester, C William ; Vermund, Sten H. ; Aliyu, Muktar H. ; Less -
Description:
Objective To assess trends in hemoglobin recovery among HIV-infected patients initiated on zidovudine-based combined antiretroviral therapy (cART) stratified by baseline hemoglobin level. Methods Hemoglobin data from non-pregnant adult patients initiating cART in rural north-central Nigeria between June 2009 and May 2011 was analyzed using a linear mixed effects model to assess the interaction between time, zidovudine-containing regimen, and baseline hemoglobin level on the outcome of subsequent hemoglobin level. Best fit curves were created for baseline hemoglobin in the 10th, 25th, 75th and 90th percentiles. Results We included 313 patients with 736 measures of hemoglobin in the analysis (239 on zidovudine and 74 on non-zidovudine-containing regimens). Median hemoglobin increased over time in both groups, with differences in hemoglobin response over time related to baseline hemoglobin levels and zidovudine use (p = 0.003). The groups of patients on zidovudine at the 10th and 90th percentiles had downward sloping curves while all other groups had upward trending hemoglobin levels. Conclusion Though hemoglobin levels increased overall for patients on zidovudine-containing regimens, for those in the 10th and 90th percentiles hemoglobin levels trended downward over time. These results have implications for decisions regarding when to initiate, switch from or avoid the use of zidovudine.
Subject:
[+]
Adult
Anemia
Anti-HIV Agents
Antiretroviral Therapy, Highly Active
Drug Therapy, Combination
Female
Hemoglobins
HIV Infections
Humans
Linear Models
Male
Middle Aged
Retrospective Studies
Reverse Transcriptase Inhibitors
Rural Population
Socioeconomic Factors
Time Factors
Treatment Outcome
Zidovudine

Source:
Int J STD AIDS. 25(5):355-359 ;
Pubmed ID:
24104694
Pubmed Central ID:
PMC4385388
Document Type:
Journal Article ;
Funding:
R01 HD075075/HD/NICHD NIH HHS/United States ; U2G PS001063/PS/NCHHSTP CDC HHS/United States ;
R01 HD075075/HD/NICHD NIH HHS/United States ; U2G PS001063/PS/NCHHSTP CDC HHS/United States ; Less -
Place as Subject:
Nigeria ;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:5eee0527593ca22846c02103ac0d69be05c811b90f1995bf3ae92dce4deb99f3
File Type:

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