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The Magnitude of Interferon Gamma Release Assay Responses in Children With Household Tuberculosis Contact is Associated With Tuberculosis Exposure and Disease Status
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8 01 2021
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Source: Pediatr Infect Dis J. 40(8):763-770
[PDF-734.77 KB]
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Alternative Title:Pediatr Infect Dis J
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Personal Author:
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Description:Background
The clinical utility of the magnitude of interferon gamma (IFNγ) in response to mycobacterial antigens is unknown. We assessed the association between quantitative IFNγ response and degree of M. tuberculosis exposure, infection and tuberculosis (TB) disease status in children.
Methods
We completed cross-sectional analysis of children (≤15 years) exposed to an adult with bacteriologically confirmed TB, 2007–2012 in Cape Town, South Africa. IFNγ values were reported as concentrations and spot forming units (SFU) for the QuantiFERON-TB Gold In-Tube (QFT-GIT), and T-SPOT.TB, respectively. Random effects linear regression was used to investigate the relation between the M. tuberculosis contact score, clinical phenotype (TB diseased, infected, uninfected) and IFNγ response as outcome, adjusted for relevant covariates.
Results
We analyzed data from 669 children (median age 63 months; IQR=33–108). A one-unit increase in M. tuberculosis contact score was associated with an increase of IFNγ 0.60 IU/ml (95%CI=0.44–0.76), and IFNγ SFU 2 counts (95%CI=1–3). IFNγ response was significantly lower among children with M. tuberculosis infection compared to children with TB disease (β =−1.42, 95%CI=−2.80- −0.03) for the QFT-GIT, but not for the T-SPOT.TB. This association was strongest among children 2–5 years (β =−2.35, 95%CI=−4.28- −0.42) and absent if <2 years.
Discussion
The magnitude of IFNγ response correlated with the degree of recent M. tuberculosis exposure, measured by QFT-GIT and T-SPOT.TB, and was correlated with clinically relevant TB phenotypes, using the QFT-GIT. IFNγ values are not only useful in estimating the risk of M. tuberculosis infection but may also support the diagnosis of TB disease in children.
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Pubmed ID:34050092
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Pubmed Central ID:PMC8277676
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Volume:40
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Issue:8
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