Potential Impact of Antiviral Drug Use during Influenza Pandemic

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Gani, Raymond ; Hughes, Helen ; Fleming, Douglas ; Griffin, Thomas ; Medlock, Jolyon ; Leach, Steve
• Description:
  The recent spread of highly pathogenic strains of avian influenza has highlighted the threat posed by pandemic influenza. In the early phases of a pandemic, the only treatment available would be neuraminidase inhibitors, which many countries are considering stockpiling for pandemic use. We estimate the effect on hospitalization rates of using different antiviral stockpile sizes to treat infection. We estimate that stockpiles that cover 20%-25% of the population would be sufficient to treat most of the clinical cases and could lead to 50% to 77% reductions in hospitalizations. Substantial reductions in hospitalization could be achieved with smaller antiviral stockpiles if drugs are reserved for persons at high risk.
• Subjects:
  Adolescent Adult Aged Age Distribution Antiviral Agents Child Child, Preschool Communicable Diseases, Emerging Disaster Planning Disease Outbreaks Hospitalization Humans Influenza, Human Middle Aged Neuraminidase

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• Source:
  Emerg Infect Dis. 11(9):1355-1362.
• Document Type:
  Journal Article
• Volume:
  11
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:3cc7b4c136486749771879ccbd4d25dcc62ce26645055f6e638b8600cc552bcc
• Download URL:
  https://stacks.cdc.gov/view/cdc/15805/cdc_15805_DS1.pdf
• File Type:
  [PDF - 559.24 KB ]