Fluoroquinolone-resistant Escherichia coli Carriage in Long-Term Care Facility

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Maslow, Joel N. ; Lee, Betsy ; Lautenbach, Ebbing
• Description:
  We conducted a cross-sectional study to determine the prevalence of, and risk factors for, colonization with fluoroquinolone (FQ)-resistant Escherichia coli in residents in a long-term care facility. FQ-resistant E. coli were identified from rectal swabs for 25 (51%) of 49 participants at study entry. On multivariable analyses, prior FQ use was the only independent risk factor for FQ-resistant E. coli carriage and was consistent for FQ exposures in the previous 3, 6, 9, or 12 months. Pulsed-field gel electrophoresis of FQ-resistant E. coli identified clonal spread of 1 strain among 16 residents. Loss (6 residents) or acquisition (7 residents) of FQ-resistant E. coli was documented and was associated with de novo colonization with genetically distinct strains. Unlike the case in the hospital setting, FQ-resistant E. coli carriage in long-term care facilities is associated with clonal spread.
• Subjects:
  Adult Aged Aged, 80 And Over Anti-Bacterial Agents Bacterial Carrier State Colony Count, Microbial Cross-Sectional Studies Drug Resistance Drug Resistance, Bacterial E.coli Escherichia Coli Escherichia Coli Infections Feces Female Fluoroquinolone Fluoroquinolones Humans Keywords: Molecular Epidemiology Long-Term Care Long Term Care Male Microbial Sensitivity Tests Middle Aged Nursing Home Nursing Homes Research Risk Factors

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• Source:
  Emerg Infect Dis. 11(6):889-894.
• Document Type:
  Journal Article
• Volume:
  11
• Issue:
  6
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:8cd47c09d9cd06c2c4017572c9b9bbf2aeec770d6dfda1592da6f07b9e6e8a70
• Download URL:
  https://stacks.cdc.gov/view/cdc/15801/cdc_15801_DS1.pdf
• File Type:
  [PDF - 85.12 KB ]