Norovirus Recombination in ORF1/ORF2 Overlap

Bull, Rowena A.; Hansman, Grant S.; Clancy, Leighton E.; Tanaka, Mark M.; Rawlinson, William D.; White, Peter A.

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Norovirus Recombination in ORF1/ORF2 Overlap

Supporting Files Public Domain

Jul 2005
By Bull, Rowena A. ; Hansman, Grant S. ; Clancy, Leighton E. ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Bull, Rowena A. ; Hansman, Grant S. ; Clancy, Leighton E. ; Tanaka, Mark M. ; Rawlinson, William D. ; White, Peter A.
Description:

Norovirus (NoV) genogroups I and II (GI and GII) are now recognized as the predominant worldwide cause of outbreaks of acute gastroenteritis in humans. Three recombinant NoV GII isolates were identified and characterized, 2 of which are unrelated to any previously published recombinant NoV. Using data from the current study, published sequences, database searches, and molecular techniques, we identified 23 recombinant NoV GII and 1 recombinant NoV GI isolates. Analysis of the genetic relationships among the recombinant NoV GII isolates identified 9 independent recombinant sequences; the other 14 strains were close relatives. Two of the 9 independent recombinant NoV were closely related to other recombinants only in the polymerase region, and in a similar fashion 1 recombinant NoV was closely related to another only in the capsid region. Breakpoint analysis of recombinant NoV showed that recombination occurred in the open reading frame (ORF)1/ORF2 overlap. We provide evidence to support the theory of the role of subgenomic RNA promoters as recombination hotspots and describe a simple mechanism of how recombination might occur in NoV.
Subjects:

Caliciviridae Infections Disease Outbreaks Gastroenteritis Genetic Variation Humans Norovirus Open Reading Frames Phylogeny Recombination, Genetic Research RNA, Viral Viral Proteins
Source:

Emerg Infect Dis. 11(7):1079-1085.
Document Type:

Journal Article
Place as Subject:

New South Wales, Australia
Location:

Europe ; Oceania
Volume:

11
Issue:

7
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:5f75c3bc63fb7469e3757c5e814d2b8531ef07863c264a652cc06e92978e2adb
Download URL:

https://stacks.cdc.gov/view/cdc/15791/cdc_15791_DS1.pdf
File Type:

[PDF - 244.46 KB ]

File Language:

English

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