Fluoroquinolone-resistant Escherichia coli, Indonesia

Kuntaman, Kuntaman; Lestari, Endang Sri; Severin, Juliëtte A.; Kershof, Irma M.; Mertaniasih, Ni Made; Purwanta, Marijam; Hadi, Usman; Johnson, James R.; van Belkum, Alex; Verbrugh, Henri A.

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Fluoroquinolone-resistant Escherichia coli, Indonesia

Sep 2005
By Kuntaman, Kuntaman ; Lestari, Endang Sri ; Severin, Juliëtte A. ; ...
Source: Emerg Infect Dis. 11(9):1363-1369.

[PDF-127.06 KB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Kuntaman, Kuntaman ; Lestari, Endang Sri ; Severin, Juliëtte A. ; Kershof, Irma M. ; Mertaniasih, Ni Made ; ... More +

Kuntaman, Kuntaman ; Lestari, Endang Sri ; Severin, Juliëtte A. ; Kershof, Irma M. ; Mertaniasih, Ni Made ; Purwanta, Marijam ; Hadi, Usman ; Johnson, James R. ; van Belkum, Alex ; Verbrugh, Henri A. Less -
Corporate Authors:

on behalf of the Antimicrobial Resistance in Indonesia ; Prevalence and Prevention study group

on behalf of the Antimicrobial Resistance in Indonesia ; Prevalence and Prevention study group Less -
Description:

In a recent, population-based survey of 3,996 persons in Indonesia, fluoroquinolone (FQ)-resistant Escherichia coli was prevalent in the fecal flora of 6% of patients at hospital admission and 23% of patients at discharge, but not among healthy relatives or patients visiting primary healthcare centers (2%). Molecular typing showed extensive genetic diversity with only limited clonality among isolates. This finding suggests that independent selection of resistant mutants occurs frequently. FQ-resistant isolates exhibited a higher rate of spontaneous mutation, but sparser virulence profiles, than FQ-susceptible isolates from the same population. The resistant isolates belonged predominantly to phylogenetic groups A (57%) and B1 (22%) but also to the moderately virulent group D (20%). Hypervirulent strains from the B2 cluster were underrepresented (1%). Because FQ-resistant E. coli can cause disease, especially nosocomial infections in immunocompromised patients, spread of such strains must be stopped.
Subjects:

[+]

Anti-Infective Agents Drug Resistance, Bacterial Fluoroquinolones Genetics, Population Humans Microbial Sensitivity Tests Molecular Biology Phylogeny Research
Source:

Emerg Infect Dis. 11(9):1363-1369.
Document Type:

Journal Article
Place as Subject:

Indonesia
Location:

Asia
Volume:

11
Issue:

9
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:a1364492490c05188210d4df11a66b244e446b02c0ef649304013612e501e480
Download URL:

https://stacks.cdc.gov/view/cdc/15775/cdc_15775_DS1.pdf
File Type:

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