Community-associated Methicillin-resistant Staphylococcus aureus, Canada

Mulvey, Michael R.; MacDougall, Laura; Cholin, Brenda; Horsman, Greg; Fidyk, Melanie; Woods, Shirley

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Community-associated Methicillin-resistant Staphylococcus aureus, Canada

Supporting Files Public Domain

Jun 2005
By Mulvey, Michael R. ; MacDougall, Laura ; Cholin, Brenda ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Mulvey, Michael R. ; MacDougall, Laura ; Cholin, Brenda ; Horsman, Greg ; Fidyk, Melanie ; Woods, Shirley
Corporate Authors:

Saskatchewan CA-MRSA Study Group
Description:

A total of 184 methicillin-resistant Staphylococcus aureus (MRSA) strains were collected from patients who sought treatment primarily for skin and soft tissue infections from January 1, 1999, to March 31, 2002, in east-central Saskatchewan, Canada. Molecular subtyping analysis using pulsed-field gel electrophoresis showed 2 major clusters. Cluster A (n = 55) was composed of a multidrug-resistant MRSA strain associated with a long-term care facility and was similar to the previously reported nosocomial Canadian epidemic strain labeled CMRSA-2. Cluster B (n = 125) was associated with cases identified at community health centers and was indistinguishable from a community-associated (CA)-MRSA strain identified previously in the United States (USA400). Cluster B remained susceptible to a number of classes of antimicrobial agents and harbored the lukF-PV and lukS-PV toxin genes. Over 50% of both clonal groups displayed high-level resistance to mupirocin. This is the first report of the USA400 strain harboring the lukF-PV and lukS-PV toxin genes in Canada.
Subjects:

Adolescent Adult Aged Anti-Bacterial Agents Bacterial Proteins Bacterial Toxins Child Communicable Diseases, Emerging Community-Acquired Infections Exotoxins Humans Leukocidins Methicillin Resistance Microbial Sensitivity Tests Middle Aged Saskatchewan Soft Tissue Infections Staphylococcal Infections Staphylococcal Skin Infections Staphylococcus Aureus
Source:

Emerg Infect Dis. 11(6):844-850.
Document Type:

Journal Article
Volume:

11
Issue:

6
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:79af00d643b2d004ba61868cb61cdd292b44e22349475789177b64ec3543bff8
Download URL:

https://stacks.cdc.gov/view/cdc/15761/cdc_15761_DS1.pdf
File Type:

[PDF - 207.65 KB ]

File Language:

English

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