Chest Radiograph Screening for Detecting Subclinical Tuberculosis in Asymptomatic Household Contacts, Peru

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Tan, Qi ; Huang, Chuan-Chin ; Becerra, Mercedes C. ; Calderon, Roger ; Contreras, Carmen ; Lecca, Leonid ; Jimenez, Judith ; Yataco, Rosa ; Galea, Jerome T. ; Feng, Jia-Yih ; Pan, Sheng-Wei ; Tseng, Yen-Han ; Huang, Jhong-Ru ; Zhang, Zibiao ; Murray, Megan B.
• Description:
  The World Health Organization's end TB strategy promotes the use of symptom and chest radiograph screening for tuberculosis (TB) disease. However, asymptomatic early states of TB beyond latent TB infection and active disease can go unrecognized using current screening criteria. We conducted a longitudinal cohort study enrolling household contacts initially free of TB disease and followed them for the occurrence of incident TB over 1 year. Among 1,747 screened contacts, 27 (52%) of the 52 persons in whom TB subsequently developed during follow-up had a baseline abnormal radiograph. Of contacts without TB symptoms, persons with an abnormal radiograph were at higher risk for subsequent TB than persons with an unremarkable radiograph (adjusted hazard ratio 15.62 [95% CI 7.74-31.54]). In young adults, we found a strong linear relationship between radiograph severity and time to TB diagnosis. Our findings suggest chest radiograph screening can extend to detecting early TB states, thereby enabling timely intervention.
• Subjects:
  Adolescent Adult Child Child, Preschool Contact Tracing Family Characteristics Female Humans Infant Latent Tuberculosis Longitudinal Studies Male Mass Screening Middle Aged Radiography, Thoracic Tuberculosis Tuberculosis, Pulmonary Young Adult

  More +
• Keywords:
  Bacteria Chest Radiography Contact Tracing Global Health Mass Chest X-ray Peru Pulmonary Subclinical Infections Tuberculosis And Other Mycobacteria
• Source:
  Emerg Infect Dis. 2024; 30(6):1115-1124
• Pubmed ID:
  38781680
• Pubmed Central ID:
  PMC11138965
• Document Type:
  Journal Article
• Place as Subject:
  Peru
• Volume:
  30
• Issue:
  6
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:803a77cd9f186a0a2bbcc3bca6f12e7ddd9210fde8d4f438c29f4ac74569d0f0
• Download URL:
  https://stacks.cdc.gov/view/cdc/156990/cdc_156990_DS1.pdf
• File Type:
  [PDF - 1.08 MB ]