Neutralizing Antibody Response and SARS Severity

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Ho, Mei-Shang ; Chen, Wei-Ju ; Chen, Hour-Young ; Lin, Szu-Fong ; Wang, Min-Chin ; Di, Jiali ; Lu, Yen-Ta ; Liu, Ching-Lung ; Chang, Shan-Chwen ; Chao, Chung-Liang ; King, Chwan-Chuen ; Chiou, Jeng-Min ; Su, Ih-Jen ; Yang, Jyh-Yuan
• Description:
  Using the Taiwan nationwide laboratory-confirmed severe acute respiratory syndrome (SARS) database, we analyzed neutralizing antibody in relation to clinical outcomes. With a linear mixed model, neutralizing antibody titer was shown to peak between week 5 and week 8 after onset and to decline thereafter, with a half-life of 6.4 weeks. Patients with a longer illness showed a lower neutralizing antibody response than patients with a shorter illness duration (p = 0.008). When early responders were compared with most patients, who seroconverted on and after week 3 of illness, the small proportion (17.4%) of early responders (antibody detectable within 2 weeks) had a higher death rate (29.6% vs. 7.8%) (Fisher exact test, p = 0.004), had a shorter survival time of <2 weeks (Fisher exact test, p = 0.013), and were more likely to be > 60 years of age (Fisher exact test, p = 0.01). Our findings have implications for understanding the pathogenesis of SARS and for SARS vaccine research and development.
• Subjects:
  Ade Adult Antibodies, Viral Antibody Decay Enzyme-Linked Immunosorbent Assay Female Humans Male Middle Aged Mortality Neutralization Tests Neutralizing Antibody Pathogenesis Research Sars Sars Virus Severe Acute Respiratory Syndrome Severity Of Illness Index

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• Source:
  Emerg Infect Dis. 11(11):1730-1737.
• Document Type:
  Journal Article
• Volume:
  11
• Issue:
  11
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:0a76c0383bc225c0da49efa5202e24b1e2988558b3ea1ac46916a94fff477d69
• Download URL:
  https://stacks.cdc.gov/view/cdc/15662/cdc_15662_DS1.pdf
• File Type:
  [PDF - 350.84 KB ]