Cell-to-cell signaling and Pseudomonas aeruginosa infections.

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Van Delden, C. ; Iglewski, B. H.
• Description:
  Pseudomonas aeruginosa is a bacterium responsible for severe nosocomial infections, life-threatening infections in immunocompromised persons, and chronic infections in cystic fibrosis patients. The bacterium's virulence depends on a large number of cell-associated and extracellular factors. Cell-to-cell signaling systems control the expression and allow a coordinated, cell-density-dependent production of many extracellular virulence factors. We discuss the possible role of cell-to-cell signaling in the pathogenesis of P. aeruginosa infections and present a rationale for targeting cell-to-cell signaling systems in the development of new therapeutic approaches.
• Subjects:
  Animals Humans Pseudomonas Aeruginosa Pseudomonas Infections Signal Transduction Virulence
• Source:
  Emerg Infect Dis. 4(4):551-560.
• Document Type:
  Journal Article
• Volume:
  4
• Issue:
  4
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:eedaf93e76815d6a18f216fd02a32510abc55d12cbdbab680494b7b7cd80e15d
• Download URL:
  https://stacks.cdc.gov/view/cdc/15543/cdc_15543_DS1.pdf
• File Type:
  [PDF - 173.90 KB ]