Population-based Prevalence and Incidence Estimates of Mixed Connective Tissue Disease from the Manhattan Lupus Surveillance Program

Details

• Alternative Title:
  Rheumatology (Oxford)
• Personal Author:
  Hasan, Ghadeer ; Ferucci, Elizabeth D. ; Buyon, Jill P. ; Belmont, H. Michael ; Salmon, Jane E. ; Askanase, Anca ; Bathon, Joan M. ; Geraldino-Pardilla, Laura ; Ali, Yousaf ; Ginzler, Ellen M. ; Putterman, Chaim ; Gordon, Caroline ; Helmick, Charles G. ; Parton, Hilary ; Izmirly, Peter M.
  More +
• Description:
  Objective: ; Epidemiologic data for mixed connective tissue disease (MCTD) are limited. Leveraging data from the Manhattan Lupus Surveillance Program (MLSP), a racially/ethnically diverse population-based registry of cases with SLE and related diseases including MCTD, we provide estimates of the prevalence and incidence of MCTD. ; Methods: ; MLSP cases were identified from rheumatologists, hospitals, and population databases using a variety of ICD-9 codes. MCTD was defined as one of the following: 1) fulfillment of our modified Alarcon-Segovia and Kahn criteria which required a positive RNP antibody and the presence of synovitis, myositis, and Raynaud's phenomenon, 2) a diagnosis of MCTD and no other diagnosis of another connective tissue disease (CTD), and 3) a diagnosis of MCTD regardless of another CTD diagnosis. ; Results: ; Overall, 258 (7.7%) of cases met a definition of MCTD. Using our modified Alarcon-Segovia and Kahn criteria for MCTD, the age-adjusted prevalence was 1.28 (95%CI 0.72-2.09) per 100,000. Using our definition of a diagnosis of MCTD and no other diagnosis of another CTD yielded an age-adjusted prevalence and incidence of MCTD of 2.98 (95%CI 2.10-4.11) per 100,000 and 0.39 (95%CI 0.22-0.64) per 100,000, respectively. The age-adjusted prevalence and incidence were highest using a diagnosis of MCTD regardless of other CTD diagnoses and were 16.22 (95%CI 14.00-18.43) per 100,000 and 1.90 (95%CI 1.49-2.39) per 100,000 respectively. ; Conclusions: ; The MLSP provided estimates for prevalence and incidence of MCTD in a diverse population. The variation in estimates using different case definitions is reflective of the challenge of defining MCTD in epidemiologic studies.
• Subjects:
  • Antibodies, Antinuclear
  • Humans
  • Incidence
  • Lupus Erythematosus, Systemic
  • Mixed Connective Tissue Disease
  • Myositis
  • Prevalence
• Keywords:
  • Mixed Connective Tissue Disease
  • Epidemiology
  • Prevalence
  • Incidence
• Source:
  Rheumatology (Oxford). 62(8):2845-2849
• Pubmed ID:
  36538873
• Pubmed Central ID:
  PMC11068036
• Document Type:
  Text
• Funding:
  U58 DP002827/DP/NCCDPHP CDC HHSUnited States/ ; U58/DP002827/HH/HHSUnited States/
• Genre:
  Journal Article
• Volume:
  62
• Issue:
  8
• Download URL:
  https://stacks.cdc.gov/view/cdc/155133/cdc_155133_DS1.pdf
• File Type:
  [PDF - 73.55 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:cfd7cb6b88914ca22e0516952675a011d429e20ac573c0b8a29ca3d4c12bccf9f21564c5b71b4caa3ea65b725e9f8415ca65ae8ee7f3fb8c1294a94202476468