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Prevalence of mixed connective tissue disease in a population-based registry of American Indian/Alaska Native people in 2007
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8 2017
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Source: Arthritis Care Res (Hoboken). 69(8):1271-1275
[PDF-312.46 KB]
Details:
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Alternative Title:Arthritis Care Res (Hoboken)
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Description:Objective:
The objective of this surveillance project was to determine the prevalence of mixed connective tissue disease (MCTD) in 2007 in the Indian Health Service (IHS) active clinical population from 3 regions of the United States.
Methods:
The IHS Lupus Registry was designed to identify possible MCTD cases as well as cases of lupus. The population denominator for this report includes American Indian or Alaska Native adults within the IHS active clinical population in 2007, residing in select communities in 3 regions of the US. Potential MCTD cases were identified using a broad range of diagnostic codes and were confirmed by detailed medical record abstraction. The primary case definition was documentation in the medical record of meeting the Alarcón-Segovia criteria for MCTD. Prevalence was calculated using two alternate definitions.
Results:
The age-adjusted prevalence of MCTD using our primary definition was 26.3 per 100,000 (95% confidence interval (CI) 17.4–38.0). The prevalence was higher in women than men using all 3 definitions, with the lowest female:male ratio of 6:1.
Conclusion:
The first population-based estimates of the prevalence of MCTD in the US American Indian/Alaska Native population show that the prevalence appears to be higher than in other populations. Additional population-based estimates are needed to better understand the epidemiology of MCTD.
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Pubmed ID:27788293
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Pubmed Central ID:PMC10533210
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Volume:69
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Issue:8
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