Campylobacter jejuni strains from patients with Guillain-Barré syndrome.

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Allos, B. M. ; Lippy, F. T. ; Carlsen, A. ; Washburn, R. G. ; Blaser, M. J.
• Description:
  Guillain-Barré syndrome (GBS), an acute demyelinating peripheral neuropathy, may be triggered by an acute infectious illness; infection with Campylobacter jejuni is the most frequently reported antecedent event. In Japan, O:19 is the most common serotype among GBS-associated C. jejuni strains. To determine whether serotype O:19 occurs among GBS-associated strains in the United States and Europe, we serotyped seven such strains and found that two (29%) of seven GBS-associated strains from patients in the United States and Germany were serotype O:19. To determine whether GBS-associated strains may be resistant to killing by normal human serum (NHS), we studied the serum susceptibility of 17 GBS- and 27 enteritis-associated strains (including many O:19 and non-O:19 strains) using C. jejuni antibody positive (pool 1) or negative (pool 2) human serum. Using pool 1 serum we found that one (6%) of 18 serotype O:19 strains compared with 11 (42%) of 26 non-O:19 strains were killed; results using pool 2 serum were nearly identical. Finally, 8 O:19 and 8 non-O:19 strains were not significantly different in their ability to bind complement component C3. Serotype O:19 C. jejuni strains were overrepresented among GBS-associated strains in the United States and Germany and were significantly more serum-resistant than non-O:19 strains. The mechanism of this resistance appears unrelated to C3 binding.
• Subjects:
  Blood Bactericidal Activity Campylobacter Infections Campylobacter Jejuni Complement C3 Humans Polyradiculoneuropathy Serotyping
• Source:
  Emerg Infect Dis. 4(2):263-268.
• Document Type:
  Journal Article
• Place as Subject:
  Germany ; United States
• Volume:
  4
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:94589b936388abd64a07a6cf16d1c76b6adedee9a86066bff33e01705dffd012
• Download URL:
  https://stacks.cdc.gov/view/cdc/15488/cdc_15488_DS1.pdf
• File Type:
  [PDF - 34.84 KB ]