Multidrug-resistant Mycobacterium tuberculosis: molecular perspectives.

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Rattan, A. ; Kalia, A. ; Ahmad, N.
• Description:
  Multidrug-resistant strains of Mycobacterium tuberculosis seriously threaten tuberculosis (TB) control and prevention efforts. Molecular studies of the mechanism of action of antitubercular drugs have elucidated the genetic basis of drug resistance in M. tuberculosis. Drug resistance in M. tuberculosis is attributed primarily to the accumulation of mutations in the drug target genes; these mutations lead either to an altered target (e.g., RNA polymerase and catalase-peroxidase in rifampicin and isoniazid resistance, respectively) or to a change in titration of the drug (e.g., InhA in isoniazid resistance). Development of specific mechanism-based inhibitors and techniques to rapidly detect multidrug resistance will require further studies addressing the drug and drug-target interaction.
• Subjects:
  Amino Acid Sequence Antitubercular Agents Base Sequence Drug Resistance, Microbial Drug Resistance, Multiple Humans Molecular Sequence Data Mutation Mycobacterium Tuberculosis Tuberculosis, Multidrug-Resistant
• Source:
  Emerg Infect Dis. 4(2):195-209.
• Document Type:
  Journal Article
• Volume:
  4
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:85ff9c628b2619ffe3942fc1501f59fc9faf77509e1aac29891b3790c3a34ce6
• Download URL:
  https://stacks.cdc.gov/view/cdc/15483/cdc_15483_DS1.pdf
• File Type:
  [PDF - 514.37 KB ]