Jail fever (epidemic typhus) outbreak in Burundi.

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Raoult, D. ; Roux, V. ; Ndihokubwayo, J. B. ; Bise, G. ; Baudon, D. ; Marte, G. ; Birtles, R.
• Description:
  We recently investigated a suspected outbreak of epidemic typhus in a jail in Burundi. We tested sera of nine patients by microimmunofluorescence for antibodies to Rickettsia prowazekii and Rickettsia typhi. We also amplified and sequenced from lice gene portions specific for two R. prowazekii proteins: the gene encoding for citrate synthase and the gene encoding for the rickettsial outer membrane protein. All patients exhibited antibodies specific for R. prowazekii. Specific gene sequences were amplified in two lice from one patient. The patients had typical clinical manifestations, and two died. Molecular techniques provided a convenient and reliable means of examining lice and confirming this outbreak. The jail-associated outbreak predates an extensive ongoing outbreak of louse-borne typhus in central eastern Africa after civil war and in refugee camps in Rwanda, Burundi (1), and Zaire.
• Subjects:
  Adult Animals Antibodies, Bacterial Base Sequence Burundi Disease Outbreaks Dna Primers Humans Male Middle Aged Phthiraptera Polymerase Chain Reaction Rickettsia Prowazekii Seroepidemiologic Studies Typhus, Epidemic Louse-Borne

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• Source:
  Emerg Infect Dis. 3(3):357-360.
• Document Type:
  Journal Article
• Volume:
  3
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:3fca6671def40551492a421d098b4736b1de0bf893aa589ca63d4c75ed9ae812
• Download URL:
  https://stacks.cdc.gov/view/cdc/15413/cdc_15413_DS1.pdf
• File Type:
  [PDF - 61.48 KB ]