Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Edwards, J. F. ; Hendricks, K. ;
Edwards, J. F. ; Hendricks, K. ; Less -
Description:
We tested the hypothesis that Cache Valley Virus (CVV), an endemic North American bunyavirus, may be involved in the pathogenesis of human neural tube defects. This investigation followed a 1990 and 1991 south Texas outbreak of neural tube defects with a high prevalence of anencephaly and the demonstration in 1987 that in utero infection by CVV was the cause of outbreaks of central nervous system and musculoskeletal defects in North American ruminants. Sera from 74 women who gave birth to infants with neural tube defects in south Texas from 1993 through early 1995 were tested for CVV neutralizing antibody. All tested sera did not neutralize CVV. These data suggest that CVV is not involved in the induction of human neural tube defects during nonepidemic periods but do not preclude CVV involvement during epidemics. Other endemic bunyaviruses may still be involved in the pathogenesis of neural tube defects or other congenital central nervous system or musculoskeletal malformations.
Subject:
[+]
Anencephaly
Bunyaviridae Infections
Female
Humans
Neural Tube Defects
Pregnancy
Pregnancy Complications, Infectious

Source:
Emerg Infect Dis. 3(2):195-197.
Document Type:
Journal Article ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:7930701d37e54b6cff437d7295af177ac712a41826f6c5dc2b0a9c704eb1bb13
File Type:

Supporting Files

• 	9204303.nxml	txt
  	license.txt	txt

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