Vitamin D, pre-eclampsia, and preterm birth among pregnancies at high risk for pre-eclampsia: an analysis of data from a low-dose aspirin trial

Details

• Alternative Title:
  BJOG
• Personal Author:
  Gernand, AD ; Simhan, HN ; Baca, KM ; Caritis, S ; Bodnar, LM
• Description:
  Objective
  
  To examine the relation between maternal vitamin D status and risk of pre-eclampsia and preterm birth in women at high risk for pre-eclampsia.
  
  Design
  
  Analysis of prospectively collected data and blood samples from a trial of prenatal low-dose aspirin.
  
  Setting
  
  Thirteen sites across the USA.
  
  Population
  
  Women at high risk for pre-eclampsia.
  
  Methods
  
  We measured 25-hydroxyvitamin D [25(OH)D] concentrations in stored maternal serum samples drawn at 12–26 weeks’ gestation (n = 822). We used mixed effects models to examine the association between 25(OH)D and risk of pre-eclampsia and preterm birth, controlling for confounders including prepregnancy BMI and race.
  
  Main outcome measures
  
  Pre-eclampsia and preterm birth.
  
  Results
  
  Twelve percent of women were vitamin D deficient [25 (OH)D <30 nmol/l]. Women with 25(OH)D <30 versus ≥75 nmol/l had a 2.4-fold (95% CI 1.0–5.6) higher risk of early-onset pre-eclampsia (<35 weeks’ gestation) after confounder adjustment. Women with 25(OH)D <50 nmol/l had a 1.8-fold (95% CI 1.0–3.2) increased risk of preterm birth at <35 weeks compared with women who had 25(OH)D ≥75 nmol/l, which was driven by indicated preterm births at <35 weeks’ gestation [25 (OH)D <50 versus ≥75 nmol/l adjusted RR 2.5 (95% CI 1.1–5.8)]. There was no association between vitamin D status and pre-eclampsia or preterm birth at <37 weeks.
  
  Conclusion
  
  Maternal vitamin D status in the second trimester was inversely associated with risk of early-onset pre-eclampsia and preterm birth at <35 weeks in women at high risk for pre-eclampsia.
  
  
• Subjects:
  Adult Aspirin Female Fibrinolytic Agents Humans Pre-Eclampsia Pregnancy Pregnancy, High-Risk Pregnancy Complications Premature Birth Prospective Studies Randomized Controlled Trials As Topic Risk Factors Vitamin D Vitamin D Deficiency Young Adult

  More +
• Keywords:
  High-risk Pre-eclampsia Preterm Birth Vitamin D
• Source:
  BJOG. 124(12):1874-1882
• Pubmed ID:
  27704679
• Pubmed Central ID:
  PMC7845451
• Document Type:
  Journal Article
• Funding:
  UL1 RR024989/RR/NCRR NIH HHSUnited States/ ; UG1 HD027869/HD/NICHD NIH HHSUnited States/ ; U10 HD040544/HD/NICHD NIH HHSUnited States/ ; UG1 HD034116/HD/NICHD NIH HHSUnited States/ ; UG1 HD040560/HD/NICHD NIH HHSUnited States/ ; U10 HD034136/HD/NICHD NIH HHSUnited States/ ; K12 HD055882/HD/NICHD NIH HHSUnited States/ ; UG1 HD027915/HD/NICHD NIH HHSUnited States/ ; U10 HD040485/HD/NICHD NIH HHSUnited States/ ; R01 HD056999/HD/NICHD NIH HHSUnited States/ ; U10 HD034116/HD/NICHD NIH HHSUnited States/ ; U10 HD027869/HD/NICHD NIH HHSUnited States/ ; U10 HD027917/HD/NICHD NIH HHSUnited States/ ; U10 HD040560/HD/NICHD NIH HHSUnited States/ ; U10 HD034208/HD/NICHD NIH HHSUnited States/ ; UG1 HD040500/HD/NICHD NIH HHSUnited States/ ; U10 HD040512/HD/NICHD NIH HHSUnited States/ ; U10 HD040545/HD/NICHD NIH HHSUnited States/ ; U01 HD036801/HD/NICHD NIH HHSUnited States/ ; U10 HD040500/HD/NICHD NIH HHSUnited States/ ; U01 DP003177/DP/NCCDPHP CDC HHSUnited States/ ; UG1 HD040544/HD/NICHD NIH HHSUnited States/ ; UG1 HD034208/HD/NICHD NIH HHSUnited States/ ; UG1 HD040512/HD/NICHD NIH HHSUnited States/ ; U10 HD027915/HD/NICHD NIH HHSUnited States/ ; UG1 HD040545/HD/NICHD NIH HHSUnited States/ ; UG1 HD040485/HD/NICHD NIH HHSUnited States/ ; U10 HD027860/HD/NICHD NIH HHSUnited States/ ; U10 HD021410/HD/NICHD NIH HHSUnited States/ ; U10 HD036801/HD/NICHD NIH HHSUnited States/ ; M01 RR000080/RR/NCRR NIH HHSUnited States/ ; U24 HD036801/HD/NICHD NIH HHSUnited States/
• Volume:
  124
• Issue:
  12
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:cdfdeab9cc63c8bb2b64268ecb48c9ecfd4d641dc46178664106ed900ec0cbad
• Download URL:
  https://stacks.cdc.gov/view/cdc/102211/cdc_102211_DS1.pdf
• File Type:
  [PDF - 102.26 KB ]