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Vitamin D, pre-eclampsia, and preterm birth among pregnancies at high risk for pre-eclampsia: an analysis of data from a low-dose aspirin trial
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11 2017
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Source: BJOG. 124(12):1874-1882
[PDF-102.26 KB]
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Alternative Title:BJOG
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Personal Author:
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Description:Objective
To examine the relation between maternal vitamin D status and risk of pre-eclampsia and preterm birth in women at high risk for pre-eclampsia.
Design
Analysis of prospectively collected data and blood samples from a trial of prenatal low-dose aspirin.
Setting
Thirteen sites across the USA.
Population
Women at high risk for pre-eclampsia.
Methods
We measured 25-hydroxyvitamin D [25(OH)D] concentrations in stored maternal serum samples drawn at 12–26 weeks’ gestation (n = 822). We used mixed effects models to examine the association between 25(OH)D and risk of pre-eclampsia and preterm birth, controlling for confounders including prepregnancy BMI and race.
Main outcome measures
Pre-eclampsia and preterm birth.
Results
Twelve percent of women were vitamin D deficient [25 (OH)D <30 nmol/l]. Women with 25(OH)D <30 versus ≥75 nmol/l had a 2.4-fold (95% CI 1.0–5.6) higher risk of early-onset pre-eclampsia (<35 weeks’ gestation) after confounder adjustment. Women with 25(OH)D <50 nmol/l had a 1.8-fold (95% CI 1.0–3.2) increased risk of preterm birth at <35 weeks compared with women who had 25(OH)D ≥75 nmol/l, which was driven by indicated preterm births at <35 weeks’ gestation [25 (OH)D <50 versus ≥75 nmol/l adjusted RR 2.5 (95% CI 1.1–5.8)]. There was no association between vitamin D status and pre-eclampsia or preterm birth at <37 weeks.
Conclusion
Maternal vitamin D status in the second trimester was inversely associated with risk of early-onset pre-eclampsia and preterm birth at <35 weeks in women at high risk for pre-eclampsia.
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Pubmed ID:27704679
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Pubmed Central ID:PMC7845451
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