Factors Associated With Human IgG Antibody Response to Anopheles albimanus Salivary Gland Extract, Artibonite Department, Haiti, 2017

Details

• Alternative Title:
  J Infect Dis
• Personal Author:
  Jaramillo-Underwood, Alicia ; Impoinvil, Daniel ; Sutcliff, Alice ; Hamre, Karen E. S. ; Joseph, Vena ; van den Hoogen, Lotus ; Lemoine, Jean Frantz ; Ashton, Ruth A. ; Chang, Michelle A. ; Existe, Alexandre ; Boncy, Jacques ; Drakeley, Chris ; Stresman, Gillian ; Druetz, Thomas ; Eisele, Thomas ; Rogier, Eric
• Description:
  Serological data can provide estimates of human exposure to both malaria vector and parasite based on antibody responses. A multiplex bead-based assay was developed to simultaneously detect IgG to Anopheles albimanus salivary gland extract (SGE) and 23 Plasmodium falciparum antigens among 4185 participants enrolled in Artibonite department, Haiti in 2017. Logistic regression adjusted for participant- and site-level covariates and found children under 5 years and 6-15 years old had 3.7- and 5.4-fold increase in odds, respectively, of high anti-SGE IgG compared to participants >15 years. Seropositivity to P. falciparum CSP, Rh2_2030, and SEA-1 antigens was significantly associated with high IgG response against SGE, and participant enrolment at elevations under 200 m was associated with higher anti-SGE IgG levels. The ability to approximate population exposure to malaria vectors through SGE serology data is very dependent by age categories, and SGE antigens can be easily integrated into a multiplex serological assay.
• Subjects:
  Animals Anopheles Antibody Formation Antigens Child Child, Preschool Haiti Humans Immunoglobulin G Malaria Malaria, Falciparum Mosquito Vectors Plasmodium Falciparum Salivary Glands

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• Keywords:
  Anopheles Albimanus Immunoglobulin G Mosquito Saliva Multiplex Serology
• Source:
  J Infect Dis. 226(8):1461-1469
• Pubmed ID:
  35711005
• Pubmed Central ID:
  PMC10982684
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  226
• Issue:
  8
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:0ab6ca0f34aec7b4be9bd442d5d5f6aa88d175b29ac19b9f32494f020470470a
• Download URL:
  https://stacks.cdc.gov/view/cdc/153625/cdc_153625_DS1.pdf
• File Type:
  [PDF - 804.52 KB ]