A One Health Perspective on Salmonellaenterica Serovar Infantis, an Emerging Human Multidrug-Resistant Pathogen

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Mattock, Jennifer ; Chattaway, Marie Anne ; Hartman, Hassan ; Dallman, Timothy J. ; Smith, Anthony M. ; Keddy, Karen ; Petrovska, Liljana ; Manners, Emma J. ; Duze, Sanelisiwe T. ; Smouse, Shannon ; Tau, Nomsa ; Timme, Ruth ; Baker, Dave J. ; Mather, Alison E. ; Wain, John ; Langridge, Gemma C.
  More +
• Description:
  Salmonella enterica serovar Infantis presents an ever-increasing threat to public health because of its spread throughout many countries and association with high levels of antimicrobial resistance (AMR). We analyzed whole-genome sequences of 5,284 Salmonella Infantis strains from 74 countries, isolated during 1989-2020 from a wide variety of human, animal, and food sources, to compare genetic phylogeny, AMR determinants, and plasmid presence. The global Salmonella Infantis population structure diverged into 3 clusters: a North American cluster, a European cluster, and a global cluster. The levels of AMR varied by Salmonella Infantis cluster and by isolation source; 73% of poultry isolates were multidrug resistant, compared with 35% of human isolates. This finding correlated with the presence of the pESI megaplasmid; 71% of poultry isolates contained pESI, compared with 32% of human isolates. This study provides key information for public health teams engaged in reducing the spread of this pathogen.
• Subjects:
  • Animals
  • Humans
  • Salmonella enterica
  • Serogroup
  • One Health
  • Anti-Bacterial Agents
  • Salmonella
  • Poultry
  • Drug Resistance, Multiple, Bacterial
• Keywords:
  • Salmonellaenterica serovar Infantis
  • bacteria
  • eBG31
  • antimicrobial resistance
  • multidrug resistance
  • pESI
  • One Health
  • Melioidosis
  • Burkholderia pseudomallei
  • history
• Source:
  Emerg Infect Dis. 2024; 30(4):701-710
• Pubmed ID:
  38526070
• Pubmed Central ID:
  PMC10977846
• Document Type:
  Journal Article
• Volume:
  30
• Issue:
  4
• Download URL:
  https://stacks.cdc.gov/view/cdc/152948/cdc_152948_DS1.pdf
• File Type:
  [PDF - 2.35 MB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:445b31eb71736a9e2ffbe5d14ce21e2ddf6133cae8f17dcb476f88ec2a9ee21f