A One Health Perspective on Salmonellaenterica Serovar Infantis, an Emerging Human Multidrug-Resistant Pathogen

Mattock, Jennifer; Chattaway, Marie Anne; Hartman, Hassan; Dallman, Timothy J.; Smith, Anthony M.; Keddy, Karen; Petrovska, Liljana; Manners, Emma J.; Duze, Sanelisiwe T.; Smouse, Shannon; Tau, Nomsa; Timme, Ruth; Baker, Dave J.; Mather, Alison E.; Wain, John; Langridge, Gemma C.

doi:10.3201/eid3004.231031

i

A One Health Perspective on Salmonellaenterica Serovar Infantis, an Emerging Human Multidrug-Resistant Pathogen

Supporting Files Public Domain

4 2024
By Mattock, Jennifer ; Chattaway, Marie Anne ; Hartman, Hassan ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Mattock, Jennifer ; Chattaway, Marie Anne ; Hartman, Hassan ; Dallman, Timothy J. ; Smith, Anthony M. ; Keddy, Karen ; Petrovska, Liljana ; Manners, Emma J. ; Duze, Sanelisiwe T. ; Smouse, Shannon ; Tau, Nomsa ; Timme, Ruth ; Baker, Dave J. ; Mather, Alison E. ; Wain, John ; Langridge, Gemma C.
Description:

Salmonella enterica serovar Infantis presents an ever-increasing threat to public health because of its spread throughout many countries and association with high levels of antimicrobial resistance (AMR). We analyzed whole-genome sequences of 5,284 Salmonella Infantis strains from 74 countries, isolated during 1989-2020 from a wide variety of human, animal, and food sources, to compare genetic phylogeny, AMR determinants, and plasmid presence. The global Salmonella Infantis population structure diverged into 3 clusters: a North American cluster, a European cluster, and a global cluster. The levels of AMR varied by Salmonella Infantis cluster and by isolation source; 73% of poultry isolates were multidrug resistant, compared with 35% of human isolates. This finding correlated with the presence of the pESI megaplasmid; 71% of poultry isolates contained pESI, compared with 32% of human isolates. This study provides key information for public health teams engaged in reducing the spread of this pathogen.
Subjects:

Animals Anti-Bacterial Agents Drug Resistance, Multiple, Bacterial Humans One Health Poultry Salmonella Salmonella Enterica Serogroup
Keywords:

Antimicrobial Resistance Bacteria Burkholderia Pseudomallei EBG31 History Melioidosis Multidrug Resistance PESI Salmonellaenterica Serovar Infantis
Source:

Emerg Infect Dis. 2024; 30(4):701-710
Pubmed ID:

38526070
Pubmed Central ID:

PMC10977846
Document Type:

Journal Article
Volume:

30
Issue:

4
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:445b31eb71736a9e2ffbe5d14ce21e2ddf6133cae8f17dcb476f88ec2a9ee21f
Download URL:

https://stacks.cdc.gov/view/cdc/152948/cdc_152948_DS1.pdf
File Type:

[PDF - 2.35 MB ]

File Language:

English

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