Epidemiology and Antimicrobial Resistance of Serotype Infantis in the United States: Infections and Emergence of a Multidrug-resistant Strain During 1979-2022.

Details

• Alternative Title:
  Infectious Diseases (London, England), 2026, v. 58, no. 1: Epidemiology and Antimicrobial Resistance of Serotype Infantis in the United States: Infections and Emergence of a Multidrug-resistant Strain During 1979-2022.
• Journal Article:
  Infectious Diseases (London, England)
• Personal Author:
  Medalla, Felicita ; Shah, Hazel J. ; Sundararaman, Preethi ; Chen, Jessica ; Ellison, Zachary ; Verlander, Sarah ; Buuck, Sean ; Hanna, Samir ; Hoelzl, Rebecca ; Rissman, Tamara ; Trevejo, Rosalie ; Devine, Carey ; Birhane, Meseret G. ; Reynolds, Jared L. ; Caidi, Hayat ; Folster, Jason ; Tolar, Beth ; Payne, Daniel C. ; Hoekstra, Robert M. ; Watkins, Louise Francois
• Description:
  infections are a major cause of human illness in the United States.
  
  serotype Infantis has re-emerged as a leading serotype with the emergence of a multidrug-resistant
  
  Infantis strain, designated as REPJFX01 by the Centers for Disease Control and Prevention (CDC). REPJFX01, which typically contains a megaplasmid of emerging
  
  Infantis (pESI) harbouring multiple resistance genes and a chromosomal
  
  mutation conferring decreased susceptibility to ciprofloxacin, has caused human infections linked to chicken consumption.
  
  The study aimed to describe the epidemiology and antimicrobial resistance of human
  
  Infantis infections, including the emergence of REPJFX01, in the United States.
  
  The study used data from five CDC surveillance systems, with combined years from 1979 through 2022. Negative binomial and logistic regression models were used in the multivariable analyses of surveillance data.
  
  In 10 active surveillance sites, the mean annual incidence of human
  
  Infantis infections was twice as high during 2013-2022 vs. 2003-2012 (adjusted rate ratio = 1.96, 95% CI 1.75-2.20). REPJFX01 infections accounted for nearly one-third of
  
  Infantis infections during 2018-2022 (vs. 2013-2017, adjusted odds ratio = 2.09, 95% CI 1.56-2.79).
  
  Infantis infections were more likely among persons who were ≥45 years old, female, from racial and ethnic minority groups, and had
  
  isolated from urine, than infections with other common serotypes.
  
  The increase in
  
  Infantis infections during 2013-2022 was likely driven by an increase in REPJFX01 infections. Public health strategies to reduce
  
  contamination of chicken could help prevent human infections.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Salmonella enterica
  • Drug Resistance, Multiple, Bacterial
  • Salmonella Infections
  • Female
  • Anti-Bacterial Agents
  • Adult
  • Middle Aged
  • Male
  • Serogroup
  More +
• Keywords:
  • Salmonella
  • Infantis
  • pESI
  • REPJFX01
  • multidrug resistance
  • antimicrobial resistance
  • incidence
• Source:
  Infectious Diseases (London, England), 2026, v. 58, no. 1
• DOI:
  https://doi.org/10.1080/23744235.2025.2553665
• ISSN:
  2374-4235 ; 2374-4243
• Pubmed ID:
  40968390
• Pubmed Central ID:
  PMC12961576
• Document Type:
  Text
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Genre:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  108-125 (31 pdf pages)
• Volume:
  58
• Issue:
  1
• Download URL:
  https://stacks.cdc.gov/view/cdc/261057/cdc_261057_DS1.pdf
• File Type:
  [PDF - 1.10 MB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:a8a2fd53ed8b0e5b822b0db638794398ca4ad52f362b72d6c22aadc933b3b4c7be184a9484e2b557e87b9f6e7bff399bf78baa09387895425beebd4aabc4af92