Streptococcal toxic-shock syndrome: spectrum of disease, pathogenesis, and new concepts in treatment.

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Stevens, D. L.
• Description:
  Since the 1980s there has been a marked increase in the recognition and reporting of highly invasive group A streptococcal infections with or without necrotizing fasciitis associated with shock and organ failure. Such dramatic cases have been defined as streptococcal toxic-shock syndrome. Strains of group A streptococci isolated from patients with invasive disease have been predominantly M types 1 and 3 that produce pyrogenic exotoxin A or B or both. In this paper, the clinical and demographic features of streptococcal bacteremia, myositis, and necrotizing fasciitis are presented and compared to those of streptococcal toxic-shock syndrome. Current concepts in the pathogenesis of invasive streptococcal infection are also presented, with emphasis on the interaction between group A Streptococcus virulence factors and host defense mechanisms. Finally, new concepts in the treatment of streptococcal toxic-shock syndrome are discussed.
• Subjects:
  Animals Anti-Bacterial Agents Bacteremia Clindamycin Clostridium Clostridium Perfringens Debridement Drug Resistance, Microbial Endotoxins Exotoxins Fasciitis, Necrotizing Humans Mice Myositis Penicillin Resistance Penicillins Shock, Septic Streptococcal Infections Streptococcus Pyogenes Virulence

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• Source:
  Emerg Infect Dis. 1(3):69-78.
• Document Type:
  Journal Article
• Volume:
  1
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:7b5f44b93fbcb7ae4662d129f14d7fb3618e2ea843e20542ea6fab51fdfd3f39
• Download URL:
  https://stacks.cdc.gov/view/cdc/15270/cdc_15270_DS1.pdf
• File Type:
  [PDF - 77.07 KB ]