Multidrug-resistant tuberculosis in prison inmates, Azerbaijan.
Published Date:2001 Sep-Oct
Source:Emerg Infect Dis. 7(5):855-861.
Bacterial Typing Techniques
DNA-Directed RNA Polymerases
DNA Transposable Elements
Drug Resistance, Multiple, Bacterial
Microbial Sensitivity Tests
Polymorphism, Restriction Fragment Length
Description:In a tuberculosis (TB) program in the Central Penitentiary Hospital of Azerbaijan, we analyzed 65 isolates of Mycobacterium tuberculosis by IS6110-based restriction fragment-length polymorphism (RFLP) and spoligotyping. From 11 clusters associated with 33 patients, 31 isolates had an IS6110-based banding pattern characteristic of the Beijing genotype of M. tuberculosis. In addition, 15 M. tuberculosis isolates with similar RFLP patterns constituted a single group by spoligotyping, matching the Beijing genotype. Multidrug resistance, always involving isoniazid and rifampin, was seen in 34 (52.3%) of 65 isolates, with 28 belonging to the Beijing genotype.
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