Clonal expansion of sequence type (ST-)5 and emergence of ST-7 in serogroup A meningococci, Africa.

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Nicolas, P. ; Décousset, L. ; Riglet, V. ; Castelli, P. ; Stor, R. ; Blanchet, G.
• Description:
  One hundred four serogroup A meningococci in our collection, isolated in Africa from 1988 to 1999, were characterized by multilocus sequence typing (MLST). Our results and data from the Internet indicate that sequence type 5 (ST-5) strains were responsible for most of African outbreaks and sporadic cases during this period. In 1995, a new clone, characterized by ST-7 sequence, emerged and was responsible for severe outbreaks in Chad (1998) and Sudan (1999). MLST and epidemiologic data indicate that ST-5 and ST-7 represent two virulent clones. These two STs, which belong to subgroup III, differ only in the pgm locus: allele pgm3 is characteristic for ST-5 and allele pgm19 for ST-7. Subgroup III strains were responsible for two pandemics in the 1960s and 1980s. Our data show that the third subgroup III pandemic has now reached Africa.
• Subjects:
  Bacterial Typing Techniques Disease Outbreaks DNA, Bacterial Humans Meningitis, Meningococcal Neisseria Meningitidis Sequence Analysis, DNA Serotyping
• Source:
  Emerg Infect Dis. 7(5):849-854.
• Document Type:
  Journal Article
• Place as Subject:
  Africa
• Volume:
  7
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:c943cf216a1d594b20e852c506588bd15aa78bf8c356270a04f4170756db41a9
• Download URL:
  https://stacks.cdc.gov/view/cdc/15206/cdc_15206_DS1.pdf
• File Type:
  [PDF - 49.55 KB ]