Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
De Groot, A. S. ; Saint-Aubin, C. ; Bosma, A. ; Sbai, H. ; Rayner, J. ; ... More +
De Groot, A. S. ; Saint-Aubin, C. ; Bosma, A. ; Sbai, H. ; Rayner, J. ; Martin, W. Less -
Description:
Defined T cell epitopes for West Nile (WN) virus may be useful for developing subunit vaccines against WN virus infection and diagnostic reagents to detect WN virus-specific immune response. We applied a bioinformatics (EpiMatrix) approach to search the WN virus NY99 genome for HLA B*07 restricted cytotoxic T cell (CTL) epitopes. Ninety-five of 3,433 WN virus peptides scored above a predetermined cutoff, suggesting that these would be likely to bind to HLA B*07 and would also be likely candidate CTL epitopes. Compared with other methods for genome mapping, derivation of these ligands was rapid and inexpensive. Major histocompatibility complex ligands identified by this method may be used to screen T cells from WN virus-exposed persons for cell-mediated response to WN virus or to develop diagnostic reagents for immunopathogenesis studies and epidemiologic surveillance.
Subject:
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Costs And Cost Analysis
Cross Reactions
Epitope Mapping
Epitopes, T-Lymphocyte
Genome, Viral
HLA-B7 Antigen
Humans
Ligands
Peptides
Staining And Labeling
T-Lymphocytes, Cytotoxic
Time Factors
West Nile Fever
West Nile Virus

Source:
Emerg Infect Dis. 7(4):706-713.
Document Type:
Journal Article
Place as Subject:
New York
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:22e658740c5689ed390d1533786fa06ac3edff1d813160b9f4df9bf116e8a429
File Type:

Supporting Files

• 	11585536.nxml	txt
  	license.txt	txt

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