Is gastroschisis associated with county-level socio-environmental quality during pregnancy?

Krajewski, Alison K.; Patel, Achal; Gray, Christine L.; Messer, Lynne C.; Keeler, Corinna Y.; Langlois, Peter H.; Reefhuis, Jennita; Gilboa, Suzanne M.; Werler, Martha M.; Shaw, Gary M.; Carmichael, Suzan L.; Nembhard, Wendy N.; Insaf, Tabassum Z.; Feldkamp, Marcia L.; Conway, Kristin M.; Lobdell, Danelle T.; Desrosiers, Tania A.

doi:10.1002/bdr2.2250

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Is gastroschisis associated with county-level socio-environmental quality during pregnancy?

11 01 2023
By Krajewski, Alison K. ; Patel, Achal ; Gray, Christine L. ; ...
Source: Birth Defects Res. 115(18):1758-1769

Public Access Version Available on: November 01, 2024, 12:00 AM

Please check back on the date listed above.

English

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Details:

Alternative Title:

Birth Defects Res
Personal Author:

Krajewski, Alison K. ; Patel, Achal ; Gray, Christine L. ; Messer, Lynne C. ; Keeler, Corinna Y. ; ... More +

Krajewski, Alison K. ; Patel, Achal ; Gray, Christine L. ; Messer, Lynne C. ; Keeler, Corinna Y. ; Langlois, Peter H. ; Reefhuis, Jennita ; Gilboa, Suzanne M. ; Werler, Martha M. ; Shaw, Gary M. ; Carmichael, Suzan L. ; Nembhard, Wendy N. ; Insaf, Tabassum Z. ; Feldkamp, Marcia L. ; Conway, Kristin M. ; Lobdell, Danelle T. ; Desrosiers, Tania A. Less -
Corporate Authors:

The National Birth Defects Prevention Study
Description:

Background:

Gastroschisis prevalence more than doubled between 1995 and 2012. While there are individual-level risk factors (e.g., young maternal age, low body mass index), the impact of environmental exposures is not well understood.

Methods:

We used the U.S. Environmental Protection Agency’s Environmental Quality Index (EQI) as a county-level estimate of cumulative environmental exposures for five domains (air, water, land, sociodemographic, and built) and overall from 2006 to 2010. Adjusted odds ratios (aOR) and 95% confidence interval (CI) were estimated from logistic regression models between EQI tertiles (better environmental quality (reference); mid; poorer) and gastroschisis in the National Birth Defects Prevention Study from births delivered between 2006 and 2011. Our analysis included 594 cases with gastroschisis and 4105 infants without a birth defect (controls).

Results:

Overall EQI was modestly associated with gastroschisis (aOR [95% CI]: 1.29 [0.98, 1.71]) for maternal residence in counties with poorer environmental quality, compared to the reference (better environmental quality). Within domain-specific indices, only the sociodemographic domain (aOR: 1.51 [0.99, 2.29]) was modestly associated with gastroschisis, when comparing poorer to better environmental quality.

Conclusions:

Future work could elucidate pathway(s) by which components of the sociodemographic domain or possibly related psychosocial factors like chronic stress potentially contribute to risk of gastroschisis.
Keywords:

[+]

Environmental Exposure Environmental Quality Environmental Quality Index EQI Female Gastroschisis Humans Infant Maternal Age Odds Ratio Pregnancy Prevalence Sociodemographic
Source:

Birth Defects Res. 115(18):1758-1769
Pubmed ID:

37772934
Pubmed Central ID:

PMC10878499
Document Type:

Journal Article
Funding:

U01 DD001304/DD/NCBDD CDC HHSUnited States/ ; U01DD001231/ACL/ACL HHSUnited States/ ; U01 DD001227/DD/NCBDD CDC HHSUnited States/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ ; U01 DD001032/DD/NCBDD CDC HHSUnited States/

U01 DD001304/DD/NCBDD CDC HHSUnited States/ ; U01DD001231/ACL/ACL HHSUnited States/ ; U01 DD001227/DD/NCBDD CDC HHSUnited States/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ ; U01 DD001032/DD/NCBDD CDC HHSUnited States/ Less -
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:104f2395676ba4ae5fa1ffff5de0fa56e884969186cf6e433bbd8d8a24f4f163
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