Is gastroschisis associated with county-level socio-environmental quality during pregnancy?

Details

• Alternative Title:
  Birth Defects Res
• Personal Author:
  Krajewski, Alison K. ; Patel, Achal ; Gray, Christine L. ; Messer, Lynne C. ; Keeler, Corinna Y. ; Langlois, Peter H. ; Reefhuis, Jennita ; Gilboa, Suzanne M. ; Werler, Martha M. ; Shaw, Gary M. ; Carmichael, Suzan L. ; Nembhard, Wendy N. ; Insaf, Tabassum Z. ; Feldkamp, Marcia L. ; Conway, Kristin M. ; Lobdell, Danelle T. ; Desrosiers, Tania A.
• Corporate Authors:
  The National Birth Defects Prevention Study
• Description:
  Background:
  
  Gastroschisis prevalence more than doubled between 1995 and 2012. While there are individual-level risk factors (e.g., young maternal age, low body mass index), the impact of environmental exposures is not well understood.
  
  Methods:
  
  We used the U.S. Environmental Protection Agency’s Environmental Quality Index (EQI) as a county-level estimate of cumulative environmental exposures for five domains (air, water, land, sociodemographic, and built) and overall from 2006 to 2010. Adjusted odds ratios (aOR) and 95% confidence interval (CI) were estimated from logistic regression models between EQI tertiles (better environmental quality (reference); mid; poorer) and gastroschisis in the National Birth Defects Prevention Study from births delivered between 2006 and 2011. Our analysis included 594 cases with gastroschisis and 4105 infants without a birth defect (controls).
  
  Results:
  
  Overall EQI was modestly associated with gastroschisis (aOR [95% CI]: 1.29 [0.98, 1.71]) for maternal residence in counties with poorer environmental quality, compared to the reference (better environmental quality). Within domain-specific indices, only the sociodemographic domain (aOR: 1.51 [0.99, 2.29]) was modestly associated with gastroschisis, when comparing poorer to better environmental quality.
  
  Conclusions:
  
  Future work could elucidate pathway(s) by which components of the sociodemographic domain or possibly related psychosocial factors like chronic stress potentially contribute to risk of gastroschisis.
  
  
• Subjects:
  Environmental Exposure Female Gastroschisis Humans Infant Maternal Age Odds Ratio Pregnancy Prevalence
• Keywords:
  Environmental Quality Environmental Quality Index EQI Gastroschisis Sociodemographic
• Source:
  Birth Defects Res. 115(18):1758-1769
• Pubmed ID:
  37772934
• Pubmed Central ID:
  PMC10878499
• Document Type:
  Journal Article
• Funding:
  U01 DD001231/DD/NCBDD CDC HHSUnited States/ ; U01 DD001304/DD/NCBDD CDC HHSUnited States/ ; U01 DD001224/DD/NCBDD CDC HHSUnited States/ ; U01 DD001227/DD/NCBDD CDC HHSUnited States/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ ; U01 DD001300/DD/NCBDD CDC HHSUnited States/ ; U01 DD001032/DD/NCBDD CDC HHSUnited States/ ; U01 DD001037/DD/NCBDD CDC HHSUnited States/
• Volume:
  115
• Issue:
  18
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:afbfca8f03ab285b6a6a42c9171f14f27f39890e6a8424f93b75abcf69d207b9bf294405129cf4e98dd6c3d5dd55b94f1767e96fcb08ac24defce703cb41bd50
• Download URL:
  https://stacks.cdc.gov/view/cdc/150289/cdc_150289_DS1.pdf
• File Type:
  [PDF - 155.43 KB ]