Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Cummings, C. A. ; Relman, D. A.
Cummings, C. A. ; Relman, D. A. Less -
Description:
Complete genomic sequences of microbial pathogens and hosts offer sophisticated new strategies for studying host-pathogen interactions. DNA microarrays exploit primary sequence data to measure transcript levels and detect sequence polymorphisms, for every gene, simultaneously. The design and construction of a DNA microarray for any given microbial genome are straightforward. By monitoring microbial gene expression, one can predict the functions of uncharacterized genes, probe the physiologic adaptations made under various environmental conditions, identify virulence-associated genes, and test the effects of drugs. Similarly, by using host gene microarrays, one can explore host response at the level of gene expression and provide a molecular description of the events that follow infection. Host profiling might also identify gene expression signatures unique for each pathogen, thus providing a novel tool for diagnosis, prognosis, and clinical management of infectious disease.
Subject:
[+]
Algorithms
Animals
Bacteria
Gene Expression Regulation, Bacterial
Genetics, Microbial
Genomics
Genotype
Humans

Source:
Emerg Infect Dis. 6(5):513-525.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:84393882bbe328d60012b454206c80d2cf8d146952b5f4c1b249f6ea947148c4
File Type:

Supporting Files

• 	10998383.nxml	txt
  	license.txt	txt

More +